Cardinals vs. Giants Prediction and Odds - May 6, 2022

The San Francisco Giants square off with the St Louis Cardinals in MLB action at Oracle Park on Friday, beginning at 10:15PM ET.

Alex Cobb (1-1, 5.40 ERA) will get the ball for the Giants, pitting him against Jordan Hicks (1-2, 3.65 ERA) for the Cardinals.

Dimers' top betting picks for Cardinals vs. Giants, plus game predictions and best odds, are featured below.

This St Louis vs. San Francisco betting analysis is presented by PointsBet, which has an outstanding 5x $100 Risk-Free Bets offer for new customers.

Who will win Cardinals vs. Giants?

Based on state-of-the-art machine learning and data, Dimers.com has simulated Friday's Cardinals-Giants MLB matchup 10,000 times.

Dimers' proven predictive analytics model, DimersBOT, gives the Giants a 54% chance of beating the Cardinals.

More: Cardinals vs. Giants Simulated 10,000 Times

Cardinals vs. Giants Game Odds

• Run Line: Giants -1.5 (+170), Cardinals +1.5 (-182)
• Moneyline: Giants -130, Cardinals +120
• Total: Over/Under 7 (-115/+105)

Run Line, Moneyline and Over/Under

The Giants are listed as -1.5 favorites versus the Cardinals, with +170 at Caesars Sportsbook the best odds currently available.

For the underdog Cardinals (+1.5) to cover the run line, FanDuel Sportsbook has the best odds currently on offer at -182.

BetMGM currently has the best moneyline odds for the Giants at -130, which means you can risk $130 to win $100, for a total payout of $230, if they get the W.

Elsewhere, DraftKings Sportsbook currently has the best moneyline odds for the Cardinals at +120, where you can bet $100 to profit $120, earning a total payout of $220, if they win.

The Over/Under sits at 7 with BetMGM, which currently has the best odds for the Over at -115, while PointsBet currently has the best odds for the Under at +105.

As always, check out all the online sportsbooks available in your state for the best MLB odds and lines.

According to DimersBOT, the Cardinals (+1.5) are a 66% chance of covering the run line, while the 7-run Over/Under is a 51% chance of going Over.

More: Live Scores for All Major Sports

Best Bets for Cardinals vs. Giants

• Run Line: Cardinals +1.5 @ -182 via FanDuel Sportsbook (66% probability)
• Moneyline: Cardinals @ +120 via DraftKings Sportsbook (0.8% edge)
• Total: Under 7 @ +105 via PointsBet

Dimers' best bets are based on world-class simulations and betting intelligence to serve you the best possible plays 24/7/365.

While the Giants are more likely to win the game, according to DimersBOT, taking the Cardinals moneyline is the best option because of the edge found when comparing our data-led probabilities to the betting odds currently available.

Taking advantage of the edges published on Dimers.com is crucial to achieving long-term profitability as a bettor.

Furthermore, despite the Over being more likely to hit on this occasion, Under 7 is our best bet on account of the better odds (+105) that are available from PointsBet.

Cardinals vs. Giants Probabilities

Use our dynamic widget below to explore the latest Moneyline, Over/Under and Run Line probabilities and odds for St Louis vs. San Francisco, and click or tap on See Matchup for more.

Dimers has full coverage of Friday's Cardinals-Giants matchup, including pregame predictions, top betting picks, and live win probabilities.

Remember, DimersBOT updates frequently, so keep checking this article for any changes to our betting insights ahead of Cardinals vs. Giants on Friday May 6, 2022.

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Note: when you click or tap on a link on Dimers that leads to a third-party website that we have a commercial arrangement with (such as a sportsbook), we may earn a referral fee.

Cardinals vs. Giants 2022 Game Info

When do the Giants play the Cardinals?

• Date: Friday May 6, 2022
• Time: 10:15PM ET / 7:15PM PT
• Venue: Oracle Park

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Want more MLB predictions like this?

So, you liked our Cardinals vs. Giants betting analysis? Awesome. Did you know our MLB Betting News page has a detailed betting preview for every MLB matchup as soon as the sportsbooks release their odds?

That's right, our predictive analytics model then compares those odds (aka Vegas odds) against its own probabilities to find edges in the markets, which allows us to write the most reliable MLB betting previews and beat the public and the sportsbooks to the punch.

It's only a click away, so why not see for yourself?

Lastly, Dimers' Baseball Futures page is our in-house approach to revealing who will win the 2022 World Series, with our data-led probabilities matched against the best odds to win the World Series.