Cardinals vs. Giants Prediction and Odds - May 5, 2022

MLB action continues on Thursday at 9:45PM ET as the St Louis Cardinals square off with the San Francisco Giants at Oracle Park.

The Giants will have Mauricio Llovera (0-0, 3.00 ERA) start, while the Cardinals are going with Miles Mikolas (1-1, 1.52 ERA).

Dimers' best betting picks for Cardinals vs. Giants, plus game predictions and best odds, are detailed below.

This St Louis vs. San Francisco betting preview is proudly sponsored by PointsBet, which has a 5x $100 Risk-Free Bets promo for new customers.

Who will win Cardinals vs. Giants?

Based on trusted computer power and data, Dimers.com has simulated Thursday's Cardinals-Giants MLB matchup 10,000 times.

Dimers' proven predictive analytics model, DimersBOT, can't split the two teams, giving both the Cardinals and Giants a 50% chance of winning the game.

More: Cardinals vs. Giants Simulated 10K Times

Cardinals vs. Giants Game Odds

• Run Line: Giants +1.5 (-190), Cardinals -1.5 (+168)
• Moneyline: Giants -110, Cardinals +105
• Total: Over/Under 7.5 (+115/-125)

Run Line, Moneyline and Over/Under

The Giants are +1.5 underdogs against the Cardinals, with -190 at DraftKings Sportsbook the best odds currently available.

For the favored Cardinals (-1.5) to cover the run line, FanDuel Sportsbook has the best odds currently on the market at +168.

Caesars Sportsbook currently has the best moneyline odds for the Giants at -110. That means you can risk $110 to win $100, for a total payout of $210, if they get the W.

On the other hand, BetMGM currently has the best moneyline odds for the Cardinals at +105, where you can put down $100 to profit $105, earning a total payout of $205, if they win.

The Over/Under for total runs scored is set at 7.5 with Caesars Sportsbook, which currently has the best odds for the Over at +115, while PointsBet currently has the best odds for the Under at -125.

As always, check out all the sportsbooks that are available in your state for the best MLB odds and lines.

According to DimersBOT, the Giants (+1.5) are a 64% chance of covering the run line, while the 7.5-run Over/Under is a 51% chance of going Under.

More: Today's Best Bets for All Major Sports

Best Bets for Cardinals vs. Giants

• Run Line: Cardinals -1.5 @ +168 via FanDuel Sportsbook
• Moneyline: Cardinals @ +105 via BetMGM (50% probability)
• Total: Over 7.5 @ +115 via Caesars Sportsbook (2.5% edge)

Dimers' best bets are based on detailed simulations and betting intelligence to serve you the best possible plays every day of the year.

Even though the Giants are more likely to cover the run line, our best bet of Cardinals -1.5 is based on the expectation of that happening, according to DimersBOT, and the top odds available.

Furthermore, despite the Under being more likely to hit on this occasion, Over 7.5 is our best bet on account of the better odds (+115) that are available from Caesars Sportsbook.

Cardinals vs. Giants Betting Guide

Use our interactive widget below to explore up-to-date Moneyline, Over/Under and Run Line probabilities and odds for St Louis vs. San Francisco, and click or tap on See Matchup to reveal more.

Dimers has full coverage of Thursday's Cardinals-Giants matchup, including pregame predictions, free betting picks, and live win probabilities.

Remember, DimersBOT updates regularly, so refresh this page for any changes to our betting insights before Cardinals vs. Giants on Thursday May 5, 2022.

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Note: when you click or tap on a link on Dimers that leads to a third-party website that we have a commercial arrangement with (such as a sportsbook), we may earn a referral fee.

Cardinals vs. Giants 2022 Game Info

When do the Giants play the Cardinals?

• Date: Thursday May 5, 2022
• Time: 9:45PM ET / 6:45PM PT
• Venue: Oracle Park

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That's right, our predictive analytics model then compares those odds against its own probabilities to find value in the markets. This allows us to produce the most reliable MLB betting previews and get the jump on the public and the sportsbooks.

It's only a click away, so why not see for yourself?

Finally, Dimers' Baseball Futures page is our in-house approach to revealing who will win the 2022 World Series, with our data-led probabilities paired with the best odds to win the World Series.