Cardinals vs. Cubs Prediction and Odds - Aug 22, 2022

The Chicago Cubs and St. Louis Cardinals lock horns in MLB at Wrigley Field on Monday, starting at 8:05PM ET.

The Cubs will send Drew Smyly (5-6, 3.67 ERA) to the mound, up against Jordan Montgomery (6-3, 3.29 ERA) for the Cardinals.

Dimers' top betting picks for Cardinals vs. Cubs, as well as game predictions and best odds, are featured in this article.

Who will win Cardinals vs. Cubs?

Based on high-tech computer power and data, Dimers.com has simulated Monday's Cardinals-Cubs MLB matchup 10,000 times.

Dimers' renowned predictive analytics model, DimersBOT, currently gives the Cardinals a 61% chance of beating the Cubs.

More: Cardinals vs. Cubs Simulated 10K Times

Cardinals vs. Cubs Odds

• Run Line: Cubs +1.5 (-115), Cardinals -1.5 (+100)
• Moneyline: Cubs +146, Cardinals -165
• Total: Over/Under 8 (-106/-105)

Run Line, Moneyline and Over/Under

The Cubs are listed as +1.5 underdogs versus the Cardinals, with -115 at Caesars Sportsbook the best odds currently available.

For the favored Cardinals (-1.5) to cover the run line, BetMGM has the best odds currently on offer at +100.

FanDuel Sportsbook currently has the best moneyline odds for the Cubs at +146. That means you can bet $100 to profit $146, earning a total payout of $246, if they win.

Elsewhere, BetMGM currently has the best moneyline odds for the Cardinals at -165, where you can risk $165 to win $100, for a total payout of $265, if they come out on top.

The Over/Under is set at 8 with FanDuel Sportsbook, which currently has the best odds for the Over at -106, while PointsBet currently has the best odds for the Under at -105.

As always, check out the sportsbooks you have access to in your state for the best MLB odds and lines.

According to DimersBOT, the Cubs (+1.5) are a 53% chance of covering the run line, while the 8-run Over/Under is a 55% chance of going Over.

More: Free Online Bet Tracker

Best Bets for Cardinals vs. Cubs

• Run Line: Cubs +1.5 @ -115 via Caesars Sportsbook (53% probability)
• Moneyline: Cubs @ +146 via FanDuel Sportsbook
• Total: Over 8 @ -106 via FanDuel Sportsbook (55% probability)

Our best bets are based on complex modeling and betting expertise to help you make better decisions with the legal sportsbooks in the United States.

While the Cardinals are more likely to win the game, according to DimersBOT, taking the Cubs moneyline is the best option due to the edge found when comparing our data-led probabilities to the sportsbooks' odds currently on offer.

Taking advantage of the edges seen here at Dimers is crucial to being profitable in the long run.

Cardinals vs. Cubs Prediction

Use our interactive widget below to explore the latest Moneyline, Over/Under and Run Line probabilities and odds for St. Louis vs. CHI Cubs, and click or tap on See Matchup to reveal more.

Dimers has full coverage of Monday's Cardinals-Cubs matchup, including pregame predictions, free betting picks, and live scores.

Don't forget, DimersBOT updates often, so keep an eye on this page for any changes to our betting analysis before Cardinals vs. Cubs on Monday August 22, 2022.

Get a Risk-Free Bet for Cardinals vs. Cubs

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All you need to do is click or tap on this exclusive FanDuel Sportsbook link and create a new account – it's easy and takes less than 2 minutes.

Then, make your first deposit and place a bet up to $1K on Cardinals vs. Cubs. If your bet doesn't win, FanDuel Sportsbook will refund it in site credit!

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Note: When you click or tap on a link on Dimers that leads to a third-party website that we have a commercial arrangement with (such as a sportsbook), we may receive a referral fee.

Cardinals vs. Cubs 2022 Game Info

Monday's game between the Cubs and Cardinals at Wrigley Field is scheduled to start at 8:05PM ET.

• Who: Chicago Cubs vs. St. Louis Cardinals
• Date: Monday August 22, 2022
• Time: 8:05PM ET / 5:05PM PT
• Venue: Wrigley Field

Ready to join an online sportsbook and start betting on MLB today? We've listed the best available sign-up offers in each and every legal betting state.

Want more MLB predictions like this?

To get more MLB betting previews like you've just read for Cardinals vs. Cubs, all you've gotta do is visit our MLB Betting News page. It's that easy – they're all there!

We use the power of predictive analytics to find edges in the markets so we can produce the most comprehensive MLB betting previews out there. We do this by comparing our in-house probabilities against the sportsbooks' odds (aka Vegas odds) as soon as they go live.

So, get ahead of the game and beat the bookies today – it's only a click away.

Lastly, Dimers' Baseball Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities matched against the best odds to win the World Series.