Cardinals vs. Brewers Prediction and Odds - Apr 16, 2022

MLB action continues on Saturday at 7:10PM EDT as the St Louis Cardinals lock horns with the Milwaukee Brewers at American Family Field.

Adrian Houser (0-1, 4.91 ERA) will get the ball for the Brewers, up against Steven Matz (0-1, 21.00 ERA) for the Cardinals.

Dimers' top betting picks for Cardinals vs. Brewers, as well as game predictions and best odds, are featured below.

Who will win Cardinals vs. Brewers?

Based on cutting-edge machine learning and data, Dimers.com has simulated Saturday's Cardinals-Brewers MLB game 10,000 times.

Dimers' leading predictive analytics model, DimersBOT, currently gives the Cardinals a 51% chance of defeating the Brewers.

More: Cardinals vs. Brewers Simulated 10,000 Times

Cardinals vs. Brewers Odds

• Run Line: Brewers +1.5, Cardinals -1.5
• Moneyline: Brewers -115, Cardinals +102
• Total: Over/Under 8.5

Run Line, Moneyline and Over/Under

The Brewers are listed as +1.5 underdogs against the Cardinals, with -190 at DraftKings Sportsbook the best odds currently available.

For the favored Cardinals (-1.5) to cover the run line, DraftKings Sportsbook also has the best odds currently on offer at +160.

DraftKings Sportsbook currently has the best moneyline odds for the Brewers at -115. That means you can risk $115 to win $100, for a total payout of $215, if they get the W.

On the other hand, FanDuel Sportsbook currently has the best moneyline odds for the Cardinals at +102, where you can put down $100 to profit $102, earning a total payout of $202, if they win.

The Over/Under sits at 8.5 with PointsBet, which currently has the best odds for the Over at +105, while FanDuel Sportsbook currently has the best odds for the Under at -115.

As always, check out the sportsbooks you can bet with in your state for the best MLB odds and lines.

According to DimersBOT, the Brewers (+1.5) are a 53% chance of covering the run line, while the Over/Under total of 8.5 runs is considered an equal 50-50 chance of hitting.

More: Predictions for Every MLB Game

Best Bets for Cardinals vs. Brewers

• Run Line: Cardinals -1.5 @ +160 via DraftKings Sportsbook (9.0% edge) 🔥
• Moneyline: Cardinals @ +102 via FanDuel Sportsbook (51% probability)
• Total: Over 8.5 @ +105 via PointsBet (50% probability)

Every time you see a 🔥, you know you've found one of our best bets today across all major pro and college sports.

Dimers' best bets are based on complex simulations and betting intelligence to help you make smarter investments with the legal sportsbooks in America.

Although the Brewers are more likely to cover the run line, our best bet of Cardinals -1.5 is based on the chance of that happening, according to DimersBOT, and the top odds available.

Cardinals vs. Brewers Betting Guide

Use our dynamic widget below to see up-to-date Moneyline, Over/Under and Run Line probabilities and odds for St Louis vs. Milwaukee, and click or tap on See Matchup for more.

Dimers has full coverage of Saturday's Cardinals-Brewers matchup, including pre-game predictions, best betting picks, and live win probabilities.

Don't forget, DimersBOT updates often, so check this page for the latest betting insights ahead of Cardinals vs. Brewers on Saturday April 16, 2022.

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Cardinals vs. Brewers 2022 Game Info

When do the Brewers play the Cardinals?

• Date: Saturday April 16, 2022
• Time: 7:10PM EDT / 4:10PM PDT
• Venue: American Family Field

Ready to join an online sportsbook and start betting on MLB now? Check out the top sportsbook sign-up offers in your state.

What other MLB games are on today?

Now you've got the 411 on Cardinals vs. Brewers, get the latest betting predictions for all upcoming MLB games in Dimers' MLB Bet Hub, where you can find probabilities and odds, plus our best bets for each and every MLB matchup.

Want a pick for the Run Line? You got it. How about the Over/Under? Yup, got that too. The Moneyline? Yes sir. And these picks are good, I mean REALLY good. Take a look now!

Lastly, Dimers' Baseball Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities compared to the best odds to win the World Series.