Butler vs. Creighton prediction: Why Creighton is favored to win men's college basketball matchup [12/30/2025]

Creighton will face Butler in men's college basketball action at CHI Health Center Omaha on Tuesday, commencing at 9:00 PM ET.

Based on updated simulation results, Dimers' advanced college basketball model projects Creighton as the most likely winner of the Butler vs. Creighton game.

This article offers a closer look at Tuesday's matchup, including an expanded look at the predicted score, best bets and picks.

Butler vs. Creighton prediction: Who will win and cover?

Using trusted machine learning and statistical analysis, we have simulated the result of Tuesday's NCAA basketball matchup between Butler and Creighton 10,000 times as part of our men's college basketball predictions coverage.

Our leading predictive model currently gives Creighton a 70% chance of defeating Butler. Our predicted final score has Creighton winning 80-74.

According to our model, the bookmakers have got it right, and Butler and Creighton each have a 50% chance of covering the spread, while the over/under total of 155.5 points also has an equal 50-50 chance of hitting.

Butler vs. Creighton odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Butler vs. Creighton picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: