Buffalo vs. Northern Illinois prediction: Buffalo favored to win men's college basketball matchup [12/31/2025]

Northern Illinois will square off with the favored Buffalo in men's college basketball action at NIU Convocation Center on Wednesday, starting at 1:00 PM ET.

Based on updated simulation results, Dimers' advanced college basketball model predicts Buffalo as the most likely winner of the Buffalo vs. Northern Illinois game.

This article offers an expanded analysis of Wednesday's matchup, including an expanded look at the predicted score, best bets and picks.

Buffalo vs. Northern Illinois prediction: Who will win and cover?

Using innovative machine learning and statistical analysis, we have simulated the result of Wednesday's NCAA basketball matchup between Buffalo and Northern Illinois 10,000 times as part of our men's college basketball predictions coverage.

Our famous predictive model gives Buffalo a 65% chance of defeating Northern Illinois. Our predicted final score has Buffalo winning 78-74.

According to our model, Northern Illinois (+5.5) has a 58% chance of covering the spread, while the over/under total of 152.5 points has a 53% chance of staying under.

Buffalo vs. Northern Illinois odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Buffalo vs. Northern Illinois picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: