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Buffalo vs. Northern Illinois prediction: Buffalo favored to win men's college basketball matchup [12/31/2025]
Updated: | First published:
Written by Mac Douglass, Senior Editor
Get Buffalo vs Northern Illinois predictions for college basketball Wednesday.
Northern Illinois and Buffalo are scheduled to meet in men's college basketball action at NIU Convocation Center on Wednesday, starting at 1:00 PM ET.
Based on updated simulation results, Dimers' advanced college basketball model predicts Buffalo as the most likely winner of the Buffalo vs. Northern Illinois game.
This article offers a closer look at Wednesday's matchup, including an expanded look at the predicted score, best bets and picks.
Buffalo vs. Northern Illinois prediction: Who will win and cover?
Using trusted machine learning and data analysis, we have simulated the result of Wednesday's NCAA basketball matchup between Buffalo and Northern Illinois 10,000 times as part of our men's college basketball predictions coverage.
Our famous predictive model gives Buffalo a 63% chance of defeating Northern Illinois. Our predicted final score has Buffalo winning 78-74.
According to our model, Northern Illinois (+6.5) has a 58% chance of covering the spread, while the 152.5-point over/under has a 51% chance of staying under.
Buffalo vs. Northern Illinois odds
We have researched the best men's college basketball odds in America for this game, which are listed here:
| Bet Type | Buffalo | Northern Illinois |
|---|---|---|
| Spread | -6.5 (-102) | +6.5 (-118) |
| Moneyline | -270 | +225 |
| Total | o152.5 (-112) | u152.5 (-108) |
All odds are correct at the time of publication and are subject to change.
Buffalo vs. Northern Illinois picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Northern Illinois +6.5 | -118 |
| Moneyline | Northern Illinois | +225 |
| Total | Under 152.5 | -108 |
According to our men's college basketball best bets, the top play to make on this game is Northern Illinois to win.
Buffalo vs. Northern Illinois game-day updates and essential details
Wednesday's men's college basketball action between Northern Illinois and Buffalo at NIU Convocation Center is scheduled to commence at 1:00 PM ET.
- Who: Buffalo vs. Northern Illinois
- Date: Wednesday, December 31, 2025
- Time: 1:00 PM ET/10:00AM PT
- Venue: NIU Convocation Center
Conclusion
We predict Buffalo, with a 63% win probability, will likely beat Northern Illinois on Wednesday.
AI and automation have enhanced this article to quickly deliver accurate Buffalo vs. Northern Illinois insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Mac Douglass specializes in NFL previews for the NFC South and NFC East, MLB best bets, Formula 1 race previews, and professional tennis insights. Combining predictive simulations and data-driven sports analysis, Mac provides in-depth content to elevate the betting experience for sports fans.
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