Blue Jays vs. Guardians Prediction and Odds - May 6, 2022

MLB action continues on Friday at 7:10PM ET as the Toronto Blue Jays square off with the Cleveland Guardians at Progressive Field.

The Guardians will have Shane Bieber (1-1, 2.46 ERA) start, while the Blue Jays are going with Kevin Gausman (2-1, 2.27 ERA).

Dimers' top betting picks for Blue Jays vs. Guardians, plus game predictions and best odds, are detailed below.

This Toronto vs. Cleveland betting analysis is proudly sponsored by PointsBet, which has a tasty 5x $100 Risk-Free Bets offer for new users.

Who will win Blue Jays vs. Guardians?

Using state-of-the-art machine learning and data, Dimers.com has simulated Friday's Blue Jays-Guardians MLB game 10,000 times.

Dimers' revolutionary predictive analytics model, DimersBOT, currently gives the Blue Jays a 53% chance of getting the W against the Guardians.

More: Full Betting Analysis for Blue Jays vs. Guardians

Blue Jays vs. Guardians Current Odds

• Run Line: Guardians +1.5 (-149), Blue Jays -1.5 (+130)
• Moneyline: Guardians +125, Blue Jays -140
• Total: Over/Under 6.5 (-115/+100)

Run Line, Moneyline and Over/Under

The Guardians are +1.5 underdogs versus the Blue Jays, with -149 at Caesars Sportsbook the best odds currently available.

For the favored Blue Jays (-1.5) to cover the run line, DraftKings Sportsbook has the best odds currently on the market at +130.

DraftKings Sportsbook currently has the best moneyline odds for the Guardians at +125, which means you can bet $100 to profit $125, earning a total payout of $225, if they win.

Meanwhile, BetMGM currently has the best moneyline odds for the Blue Jays at -140, where you can risk $140 to win $100, for a total payout of $240, if they come out on top.

The Over/Under sits at 6.5 with Caesars Sportsbook, which currently has the best odds for the Over at -115, while BetMGM currently has the best odds for the Under at +100.

As always, make sure you check all the legal sportbooks available in your state for the best MLB odds and lines.

According to DimersBOT, the Guardians (+1.5) are a 62% chance of covering the run line, while the Over/Under total of 6.5 runs is a 57% chance of going Over.

More: Best Bets Today for All Major Sports

Best Bets for Blue Jays vs. Guardians

• Run Line: Guardians +1.5 @ -149 via Caesars Sportsbook (62% probability)
• Moneyline: Guardians @ +125 via DraftKings Sportsbook (2.8% edge)
• Total: Over 6.5 @ -115 via Caesars Sportsbook (57% probability)

Dimers' best bets are based on complex simulations and wagering intelligence to help you make more informed decisions with the legal sportsbooks in the USA.

While the Blue Jays are more likely to win the game, according to DimersBOT, betting on the Guardians moneyline is the best option because of the 2.8% edge identified when comparing our data-led probabilities to the sportsbooks' odds currently on offer.

Taking advantage of the edges published here at Dimers is one of the keys to being profitable in the long run.

Blue Jays vs. Guardians Betting Guide

Use our dynamic widget below to view the latest Moneyline, Over/Under and Run Line probabilities and odds for Toronto vs. Cleveland, and click or tap on See Matchup to reveal more.

Dimers has full coverage of Friday's Blue Jays-Guardians matchup, including pregame predictions, top betting picks, and live scores.

Remember, DimersBOT updates often, so refresh this article for any changes to our betting analysis ahead of Blue Jays vs. Guardians on Friday May 6, 2022.

Get a Risk-Free Bet for Blue Jays vs. Guardians

Do you want the best sportsbook promo in America for Toronto vs. Cleveland? Join FanDuel Sportsbook now and get your first bet risk free up to $1,000, which you can use on Friday's Blue Jays-Guardians game.

All you need to do is click or tap on this exclusive FanDuel Sportsbook link and create a new account – it's easy and takes less than 2 minutes.

Then, make your first deposit and place a bet up to $1K on Blue Jays vs. Guardians. If your bet doesn't win, FanDuel Sportsbook will refund it in site credit!

This offer is available to all new FanDuel Sportsbook users. How good is that!

Note: when you click or tap on a link on Dimers that leads to a third-party website that we have a commercial arrangement with (such as a sportsbook), we may earn a referral fee.

Blue Jays vs. Guardians 2022 Game Info

When do the Guardians play the Blue Jays?

• Date: Friday May 6, 2022
• Time: 7:10PM ET / 4:10PM PT
• Venue: Progressive Field

Enjoy Dimers.com and want to keep the site free? Every time you join a sportsbook featured here, we get paid a small fee.

These fees help us keep Dimers free for sports fans like you. So, if you like what you see, support us by joining one of our legal sports betting partners now.

Want more MLB predictions like this?

To get more MLB betting previews like you've just read for Blue Jays vs. Guardians, all you've gotta do is visit our MLB Betting News page. It's that easy – they're all there!

We use the power of predictive analytics to find value in the markets so we can write the best MLB betting previews out there. We do this by comparing our own probabilities against the sportsbooks' odds (aka Vegas odds) as soon as they go live.

So, get ahead of the game and beat the 'books today – it's only a click away.

Finally, Dimers' Baseball Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities paired with the best odds on the market.