Blue Jays vs. Guardians Prediction and Odds - May 5, 2022

The Cleveland Guardians and Toronto Blue Jays meet in MLB at Progressive Field on Thursday, starting at 6:10PM ET.

The Guardians will have Aaron Civale (0-2, 10.67 ERA) start, up against José Berríos (2-0, 4.12 ERA) for the Blue Jays.

Dimers' best betting picks for Blue Jays vs. Guardians, plus game predictions and best odds, are featured in this article.

This Toronto vs. Cleveland betting analysis is sponsored by PointsBet, which has a 5x $100 Risk-Free Bets offer for new customers.

Who will win Blue Jays vs. Guardians?

Using advanced computer power and data, Dimers.com has simulated Thursday's Blue Jays-Guardians MLB game 10,000 times.

Dimers' independent predictive analytics model, DimersBOT, gives the Blue Jays a 54% chance of getting the W against the Guardians.

More: Blue Jays vs. Guardians Simulated 10,000 Times

Blue Jays vs. Guardians Odds

• Run Line: Guardians +1.5 (-125), Blue Jays -1.5 (+115)
• Moneyline: Guardians +140, Blue Jays -145
• Total: Over/Under 8 (+105/-120)

Run Line, Moneyline and Over/Under

The Guardians are +1.5 underdogs against the Blue Jays, with -125 at DraftKings Sportsbook the best odds currently available.

For the favored Blue Jays (-1.5) to cover the run line, BetMGM has the best odds currently on offer at +115.

Caesars Sportsbook currently has the best moneyline odds for the Guardians at +140, which means you can bet $100 to profit $140, earning a total payout of $240, if they win.

Meanwhile, DraftKings Sportsbook currently has the best moneyline odds for the Blue Jays at -145, where you can risk $145 to win $100, for a total payout of $245, if they come out on top.

The Over/Under sits at 8 with Caesars Sportsbook, which currently has the best odds for the Over at +105, while DraftKings Sportsbook currently has the best odds for the Under at -120.

As always, make sure you check all the legal sportbooks that are available in your state for the best MLB odds and lines.

According to DimersBOT, the Guardians (+1.5) are a 57% chance of covering the run line, while the 8-run Over/Under is a 52% chance of going Over.

More: Predictions for Every MLB Matchup

Best Bets for Blue Jays vs. Guardians

• Run Line: Guardians +1.5 @ -125 via DraftKings Sportsbook (57% probability)
• Moneyline: Guardians @ +140 via Caesars Sportsbook (4.5% edge) 🔥
• Total: Over 8 @ +105 via Caesars Sportsbook (52% probability)

When you see a 🔥, you know you've found one of our best free picks of the day across any sport.

Dimers' best bets are based on world-class simulations and betting intelligence to serve you the best possible plays 24/7.

While the Blue Jays are more likely to win the game, according to DimersBOT, taking the Guardians moneyline is the best option because of the 4.5% edge found when comparing our data-led probabilities to the betting odds currently available.

Taking advantage of the edges published on Dimers.com is pivotal to achieving long-term profitability.

Blue Jays vs. Guardians Probabilities

Use our interactive widget below to see the latest Moneyline, Over/Under and Run Line probabilities and odds for Toronto vs. Cleveland, and click or tap on See Matchup to reveal more.

Dimers has full betting coverage of Thursday's Blue Jays-Guardians matchup, including pregame predictions, best betting picks, and live updates.

Don't forget, DimersBOT updates regularly, so refresh this page for the latest betting analysis before Blue Jays vs. Guardians on Thursday May 5, 2022.

Risk-Free Bet for Blue Jays vs. Guardians

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Blue Jays vs. Guardians 2022 Game Info

When do the Guardians play the Blue Jays?

• Date: Thursday May 5, 2022
• Time: 6:10PM ET / 3:10PM PT
• Venue: Progressive Field

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What other MLB games are on today?

The Blue Jays and Guardians aren't the only two MLB teams you can bet on today. DimersBOT never stops and we've got picks and top bets for every single MLB game via our MLB Predictions page.

Not only do we provide with you top-notch predictions, but we also have recommended bets for the Run Line, Over/Under and Moneyline. Sound good? Hell yeah it does!

While you're here, Dimers' Baseball Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities compared to the best odds available.