Best MLB Betting Picks, Predictions and Parlays: Tuesday September 21, 2021

We have officially entered the silly season section of the MLB regular season. With teams coming toward the end of the year or looking to preserve their squad before the postseason, this is the time to expect the unexpected. Let's try and navigate the stormy waters with our three best picks for Tuesday's slate.

It's Tuesday September 21, 2021, and, as always, we've simulated all of the day's MLB games 10,000 times each to determine where the value lies for baseball bettors across the United States.

With MLB betting picks, probabilities, odds and predicted scores featured each and every day, check out our top plays for Tuesday's MLB games by reading this article.

Today's MLB best bets and odds are proudly brought to you by Caesars Sportsbook.

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Free MLB Picks For Tuesday September 21, 2021

White Sox vs. Tigers

BET: Total runs OVER 9.5 with Caesars (-105)

📈 52% probability

After dropping the series opener to Detroit last night, Chicago look like they're one of the teams already trying to keep their big guns on ice until the postseason. Carlos Rodon, who started for the Sox yesterday, only gave three innings before being replaced in the 4-3 loss. Dallas Keuchel will be on the mound tonight, and while it's not clear how long he'll stay there, his 5.23 ERA is enough to get us excited about the potential for runs in this one. Starting Tigers pitcher Tyler Alexander gives up an average of one hit per inning pitched as well, leaving enough opportunity on both sides of offense for this Over total to cash.

MORE: White Sox vs. Tigers simulator

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Blue Jays vs. Rays

BET: Total runs OVER 7.5 with Caesars (-120)

📈 59% probability

The run total is low here because both Toronto and Tampa Bay will be sending in two of their better pitchers, but are we sure that's enough against sheer firepower? The Blue Jays and Rays have possess the first and third best run offense in the league and score runs, no matter who they are facing on the bump. Our data projections has this one taking advantage of the low total set by the 'books. 

MORE: Blue Jays vs. Rays simulator

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Astros vs. Angels

BET: Total runs OVER 8.5 with Caesars (-115)

📈 61% probability

It's rare that our data model returns to us a probability this high, so when it does, we have to bet it. The Astros, who are in the top 3 for run offense, put 10 past the Halos last night in a dominant display. The Angels, who have the second worst run defense in the league, could see more of the same tonight with Packy Naughton taking to the mound. Naughton was turfed after 2.2 innings last week against the White Sox after giving up 4 runs. Against these methodical Houston hitters, it could be more of the same tonight.

MORE: Astros vs. Angels simulator

Your game not here? Find out who we're betting on for every baseball game on Tuesday via our MLB Bet Hub, where we deliver you MLB predictions and suggested bets.

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MLB Parlay For Tuesday, September 21, 2021

🔥 White Sox/Tigers o9.5 runs
🔥 Blue Jays/Rays o7.5 runs
🔥 Astros/Angels o8.5 runs

Parlay Odds +569

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