MLB- More Betting
Astros vs. Twins Prediction and Odds - May 12, 2022

The Minnesota Twins take on the Houston Astros in MLB action at Target Field on Thursday, starting at 3:45PM ET.
Josh Winder (2-0, 1.61 ERA) will be on the bump for the Twins, up against Luis Garcia (2-1, 3.45 ERA) for the Astros.
Dimers' best betting picks for Astros vs. Twins, as well as game predictions and best odds, are detailed in this article.
Today's Houston vs. Minnesota betting preview is sponsored by PointsBet, which has a 5x $100 Risk-Free Bets promo for new customers.
Who will win Astros vs. Twins?
Based on trusted computer power and data, Dimers.com has simulated Thursday's Astros-Twins MLB game 10,000 times.
Dimers' leading predictive analytics model, DimersBOT, gives the Astros a 55% chance of beating the Twins.
More: Astros vs. Twins Simulated 10,000 Times
Astros vs. Twins Odds
- Run Line: Twins +1.5 (-145), Astros -1.5 (+130)
- Moneyline: Twins +120, Astros -135
- Total: Over/Under 8 (-105/-105)
Run Line, Moneyline and Over/Under
The Twins are listed as +1.5 underdogs versus the Astros, with -145 at PointsBet the best odds currently available.
For the favored Astros (-1.5) to cover the run line, FanDuel Sportsbook has the best odds currently on offer at +130.
PointsBet currently has the best moneyline odds for the Twins at +120, which means you can bet $100 to profit $120, earning a total payout of $220, if they win.
On the other hand, DraftKings Sportsbook currently has the best moneyline odds for the Astros at -135, where you can risk $135 to win $100, for a total payout of $235, if they come out on top.
The Over/Under for total runs scored sits at 8 with PointsBet, which currently has the best odds for the Over at -105, while FanDuel Sportsbook currently has the best odds for the Under at -105.
As always, make sure you check the sportsbooks you can bet with in your state for the best MLB odds and lines.
According to DimersBOT, the Twins (+1.5) are a 58% chance of covering the run line, while the Over/Under total of 8 runs is a 54% chance of going Over.
More: Best Bets for Every MLB Matchup
Best Bets for Astros vs. Twins
- Run Line: Twins +1.5 @ -145 via PointsBet (58% probability)
- Moneyline: Twins @ +120 via PointsBet
- Total: Over 8 @ -105 via PointsBet (54% probability)
Dimers' best bets are based on detailed simulations and betting intelligence to help you make more informed decisions with the legal sportsbooks in your state.
While the Astros are more likely to win the game, according to DimersBOT, taking the Twins moneyline is the best option due to the edge identified when comparing our data-led probabilities to the betting odds currently on offer.
Taking advantage of the edges published on Dimers is pivotal to being a profitable bettor in the long run.
Astros vs. Twins Probabilities
Use our interactive widget below to explore the latest Moneyline, Over/Under and Run Line probabilities and odds for Houston vs. Minnesota, and click or tap on See Matchup for more.
Dimers has full betting coverage of Thursday's Astros-Twins matchup, including pregame predictions, top betting picks, and live scores.
Don't forget, DimersBOT updates regularly, so check this article for any changes to our betting analysis before Astros vs. Twins on Thursday May 12, 2022.
Get a Risk-Free Bet for Astros vs. Twins
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Note: when you click or tap on a link on Dimers that leads to a third-party website that we have a commercial arrangement with (such as a sportsbook), we may earn a referral fee.
Astros vs. Twins 2022 Game Info
Thursday's action between the Twins and Astros at Target Field will commence at 3:45PM ET.
- Date: Thursday May 12, 2022
- Time: 3:45PM ET / 12:45PM PT
- Venue: Target Field
Looking to join an online sportsbook and start betting on MLB now? We've listed the best available welcome offers for each and every legal betting state.
What MLB games are on today?
The Astros and Twins aren't the only two MLB teams you can bet on. DimersBOT never stops and we've got picks and top bets for each and every MLB matchup via our MLB Predictions section.
Not only do we provide with you top-notch predictions, but we also have recommended bets for the Run Line, Over/Under and Moneyline. Sound good? Hell yeah it does!
Finally, Dimers' MLB Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities matched against the best odds available.
