Astros vs. Red Sox Prediction and Odds - May 16, 2022

The Boston Red Sox take on the Houston Astros at Fenway Park on Monday, starting at 7:10PM ET.

The Red Sox will have Garrett Whitlock (1-1, 2.19 ERA) start, while the Astros will counter with Jake Odorizzi (3-2, 3.38 ERA).

Dimers' free betting picks for Astros vs. Red Sox, plus game predictions and best odds, are detailed below.

Today's Houston vs. Boston betting analysis is presented by PointsBet, which has a tasty 5x $100 Risk-Free Bets offer for new users.

Who will win Astros vs. Red Sox?

Based on trusted machine learning and data, Dimers.com has simulated Monday's Astros-Red Sox MLB game 10,000 times.

Dimers' popular predictive analytics model, DimersBOT, gives the Red Sox a 54% chance of defeating the Astros .

More: Astros vs. Red Sox Simulated 10K Times

Astros vs. Red Sox Odds

• Run Line: Red Sox -1.5 (+155), Astros +1.5 (-175)
• Moneyline: Red Sox -120, Astros +114
• Total: Over/Under 9 (-120/+110)

Run Line, Moneyline and Over/Under

The Red Sox are -1.5 favorites versus the Astros, with +155 at DraftKings Sportsbook the best odds currently available.

For the underdog Astros (+1.5) to cover the run line, BetMGM has the best odds currently on offer at -175.

DraftKings Sportsbook currently has the best moneyline odds for the Red Sox at -120. That means you can risk $120 to win $100, for a total payout of $220, if they get the W.

Meanwhile, FanDuel Sportsbook currently has the best moneyline odds for the Astros at +114, where you can bet $100 to profit $114, earning a total payout of $214, if they win.

The Over/Under for total runs scored is set at 9 with BetMGM, which currently has the best odds for the Over at -120, while Caesars Sportsbook currently has the best odds for the Under at +110.

As always, check out all the legal sportbooks that are available in your state for the best MLB odds and lines.

According to DimersBOT, the Astros (+1.5) are a 63% chance of covering the run line, while the Over/Under total of 9 runs is a 56% chance of going Over.

More: Best Bets Today for All Major Sports

Best Bets for Astros vs. Red Sox

• Run Line: Astros +1.5 @ -175 via BetMGM (63% probability)
• Moneyline: Red Sox @ -120 via DraftKings Sportsbook (54% probability)
• Total: Over 9 @ -120 via BetMGM (56% probability)

Dimers' best bets are based on world-class simulations and betting intelligence to bring you the best possible plays every day of the year.

Astros vs. Red Sox Probabilities

Use our interactive widget below to explore up-to-date Moneyline, Over/Under and Run Line probabilities and odds for Houston vs. Boston, and click or tap on See Matchup to reveal more.

Dimers has full coverage of Monday's Astros-Red Sox matchup, including pregame predictions, free betting picks, and live scores.

Don't forget, DimersBOT updates frequently, so refresh this page for any changes to our betting analysis before Astros vs. Red Sox on Monday May 16, 2022.

Get a Risk-Free Bet for Astros vs. Red Sox

Do you want the best sportsbook promo in America for Houston vs. Boston? Join FanDuel Sportsbook today and get your first bet risk free up to $1,000, which you can use on Monday's Astros-Red Sox game.

All you need to do is click or tap on this exclusive FanDuel Sportsbook link and create a new account – it's easy and takes less than 2 minutes.

Then, make your first deposit and place a bet up to $1,000 on Astros vs. Red Sox. If your bet doesn't win, FanDuel Sportsbook will refund it in site credit!

This promo is available to all new FanDuel Sportsbook users – no promo code needed!

Note: when you click or tap on a link on Dimers that leads to a third-party website that we have a commercial arrangement with (such as a sportsbook), we may earn a referral fee.

Astros vs. Red Sox 2022 Game Info

Monday's game between the Red Sox and Astros at Fenway Park is scheduled to start at 7:10PM ET.

• Date: Monday May 16, 2022
• Time: 7:10PM ET / 4:10PM PT
• Venue: Fenway Park

Looking to join an online sportsbook and start betting on MLB today? Check out the best sports betting offers in your state.

What MLB games are on today?

Now you've got the 411 on Astros vs. Red Sox, check out the latest betting analysis for all upcoming MLB games in our MLB Bet Hub, where you can find probabilities and odds, plus our best bets for each and every MLB matchup.

Want a pick for the Run Line? You got it. How about the Over/Under? Yup, got that too. The Moneyline? Yes sir. And these picks are good, I mean REALLY good. Take a look now!

Lastly, Dimers' Baseball Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities matched against the best odds on the market.