Astros vs. Mariners Prediction and Odds - Apr 16, 2022

The Seattle Mariners and Houston Astros meet in the MLB at T-Mobile Park on Saturday, starting at 9:10PM EDT.

The Mariners will send Chris Flexen (0-1, 6.23 ERA) to the mound, up against Justin Verlander (0-1, 1.80 ERA) for the Astros.

Dimers' free betting picks for Astros vs. Mariners, as well as game predictions and best odds, are featured below.

Who will win Astros vs. Mariners?

Using trusted machine learning and data, Dimers.com has simulated Saturday's Astros-Mariners MLB matchup 10,000 times.

Dimers' famous predictive analytics model, DimersBOT, gives the Astros a 57% chance of beating the Mariners.

More: Astros vs. Mariners Simulated 10,000 Times

Astros vs. Mariners Current Odds

• Run Line: Mariners +1.5, Astros -1.5
• Moneyline: Mariners +135, Astros -141
• Total: Over/Under 7.5

Run Line, Moneyline and Over/Under

The Mariners are +1.5 underdogs versus the Astros, with -130 at BetMGM the best odds currently available.

For the favored Astros (-1.5) to cover the run line, FanDuel Sportsbook has the best odds currently on offer at +116.

BetMGM currently has the best moneyline odds for the Mariners at +135. That means you can bet $100 to profit $135, earning a total payout of $235, if they win.

Meanwhile, Caesars Sportsbook currently has the best moneyline odds for the Astros at -141, where you can risk $141 to win $100, for a total payout of $241, if they come out on top.

The Over/Under for total runs scored is set at 7.5 with DraftKings Sportsbook, which currently has the best odds for the Over at +100, while PointsBet currently has the best odds for the Under at -115.

As always, check out all the sportsbooks that are available in your state for the best MLB odds and lines.

According to DimersBOT, the Mariners (+1.5) are a 55% chance of covering the run line, while the Over/Under total of 7.5 runs is a 55% chance of going Over.

More: Live Scores for All Major Sports

Best Bets for Astros vs. Mariners

• Run Line: Astros -1.5 @ +116 via FanDuel Sportsbook
• Moneyline: Mariners @ +135 via BetMGM (0.1% edge)
• Total: Over 7.5 @ +100 via DraftKings Sportsbook (55% probability) 🔥

When you see a 🔥, that means it's one of our best free picks today across all major pro and college sports.

Dimers' best bets are based on complex simulations and wagering intelligence to serve you the best possible plays 24/7.

Even though the Mariners are more likely to cover the run line, our best bet of Astros -1.5 is based on the likelihood of that happening, according to DimersBOT, and the best odds available.

And while the Astros are more likely to win the game, according to DimersBOT, betting on the Mariners moneyline is the best option due to the edge identified when comparing our data-led probabilities to the betting odds currently available.

Taking advantage of the edges seen here at Dimers is pivotal to achieving long-term profitability.

Astros vs. Mariners Betting Guide

Use our dynamic widget below to explore up-to-date Moneyline, Over/Under and Run Line probabilities and odds for Houston vs. Seattle, and click or tap on See Matchup to reveal more.

Dimers has full coverage of Saturday's Astros-Mariners matchup, including pre-game predictions, free betting picks, and live win probabilities.

Remember, DimersBOT updates often, so keep an eye on this page for any changes to our betting insights before Astros vs. Mariners on Saturday April 16, 2022.

Best Sportsbook Promo for Astros vs. Mariners

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Note: when you click or tap on a link on Dimers that leads to a third-party website that we have a commercial arrangement with (such as a sportsbook), we may earn a referral fee.

Astros vs. Mariners 2022 Game Info

When do the Mariners play the Astros?

• Date: Saturday April 16, 2022
• Time: 9:10PM EDT / 6:10PM PDT
• Venue: T-Mobile Park

Ready to join an online sportsbook and start betting on MLB now? We've listed the best available sign-up offers for every legal betting state.

What MLB games are on today?

Now you've got the 411 on Astros vs. Mariners, take a look at the latest betting analysis for all upcoming MLB games in Dimers' MLB Bet Hub. There you can find probabilities and odds, and our best bets for each and every MLB matchup.

Want a pick for the Run Line? You got it. How about the Over/Under? Yup, got that too. The Moneyline? Yes sir. And these picks are good, I mean REALLY good. Take a look now!

Finally, Dimers' Baseball Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities matched against the best odds available.