Astros vs. D-Backs Prediction and Odds - Apr 13, 2022

MLB action continues on Wednesday at 3:40PM EDT as the Houston Astros square off with the Arizona D-Backs at Chase Field.

Merrill Kelly (0-0, 0.00 ERA) will get the ball for the D-Backs, up against Framber Valdez (1-0, 0.00 ERA) for the Astros.

Dimers' top betting picks for Astros vs. D-Backs, as well as game predictions and best odds, are detailed in this article.

Who will win Astros vs. D-Backs?

Using state-of-the-art machine learning and data, Dimers.com has simulated Wednesday's Astros-D-Backs MLB game 10,000 times.

Dimers' independent predictive analytics model, DimersBOT, gives the Astros a 61% chance of defeating the D-Backs.

More: Full Betting Analysis for Astros vs. D-Backs

Astros vs. D-Backs Current Odds

• Run Line: D-Backs +1.5, Astros -1.5
• Moneyline: D-Backs +140, Astros -160
• Total: Over/Under 8.5

Run Line, Moneyline and Over/Under

The D-Backs are currently +1.5 underdogs against the Astros, with -115 at Caesars Sportsbook the best odds currently available.

For the favored Astros (-1.5) to cover the run line, BetMGM has the best odds currently on offer at +100.

DraftKings Sportsbook currently has the best moneyline odds for the D-Backs at +140, which means you can bet $100 to profit $140, earning a total payout of $240, if they win.

Elsewhere, BetMGM currently has the best moneyline odds for the Astros at -160, where you can risk $160 to win $100, for a total payout of $260, if they come out on top.

The Over/Under is set at 8.5 with PointsBet, which currently has the best odds for the Over at -105, while DraftKings Sportsbook currently has the best odds for the Under at -105.

As always, make sure you check all the online sportsbooks that are available in your state for the best MLB odds and lines.

According to DimersBOT, the D-Backs (+1.5) are a 51% chance of covering the run line, while the 8.5-run Over/Under is a 52% chance of going Over.

More: Best Bets for Every MLB Matchup

Best Bets for Astros vs. D-Backs

• Run Line: Astros -1.5 @ +100 via BetMGM
• Moneyline: Astros @ -160 via BetMGM (61% probability)
• Total: Over 8.5 @ -105 via PointsBet (52% probability)

Dimers' best bets are based on detailed simulations and wagering intelligence to bring you the best possible plays 24/7/365.

Even though the D-Backs are more likely to cover the run line, our best bet of Astros -1.5 is based on the likelihood of that happening, according to DimersBOT, and the top odds available.

Astros vs. D-Backs Probabilities

Use our dynamic widget below to explore the latest Moneyline, Over/Under and Run Line probabilities and odds for Houston vs. Arizona, and click or tap on See Matchup for more.

Dimers has full coverage of Wednesday's Astros-D-Backs matchup, including pre-game predictions, free picks, and live win probabilities.

Remember, DimersBOT updates regularly, so keep an eye on this article for the latest betting insights ahead of Astros vs. D-Backs on Wednesday April 13, 2022.

Risk-Free Bet for Astros vs. D-Backs

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Simply click or tap on this exclusive FanDuel Sportsbook link and create a new account – it's easy and takes less than 2 minutes.

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Note: when you click or tap on a link on Dimers that leads to a third-party website that we have a commercial arrangement with (such as a sportsbook), we may earn a referral fee.

Astros vs. D-Backs 2022 Game Info

When do the D-Backs play the Astros?

• Date: Wednesday April 13, 2022
• Time: 3:40PM EDT / 12:40PM PDT
• Venue: Chase Field

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What MLB games are on today?

Now you've got the 411 on Astros vs. D-Backs, get the latest betting predictions for all upcoming MLB games in Dimers' MLB Bet Hub, where you can find probabilities and odds, plus our best bets for each and every MLB matchup.

Want a pick for the Run Line? You got it. How about the Over/Under? Yup, got that too. The Moneyline? Yes sir. And these picks are good, I mean REALLY good. Take a look now!

While you're here, Dimers' MLB Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities compared to the best odds to win the World Series.