Arkansas State vs. Southern Miss prediction: Arkansas State favored to win men's college basketball matchup [12/20/2025]

Southern Miss and Arkansas State will lock horns in men's college basketball action at Reed Green Coliseum on Saturday, starting at 4:30 PM ET.

Based on the latest simulations, Dimers' proven college basketball model predicts Arkansas State as the most likely winner of the Arkansas State vs. Southern Miss game.

This article offers a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

Arkansas State vs. Southern Miss prediction: Who will win and cover?

Using trusted machine learning and data analysis, we have simulated the result of Saturday's NCAA basketball game between Arkansas State and Southern Miss 10,000 times as part of our men's college basketball predictions coverage.

Our independent predictive model currently gives Arkansas State a 57% chance of beating Southern Miss. Our predicted final score has Arkansas State winning 76-74.

According to our model, Southern Miss (+2.5) has a 56% chance of covering the spread, while the 156.5-point over/under has a 55% chance of staying under.

Arkansas State vs. Southern Miss odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Arkansas State vs. Southern Miss picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: