Angels vs. Astros Prediction and Odds - Apr 20, 2022

The Houston Astros take on the Los Angeles Angels in MLB action at Minute Maid Park on Wednesday, beginning at 6:40PM EDT.

The Astros will send Jake Odorizzi (0-1, 6.48 ERA) to the mound, up against Shohei Ohtani (0-2, 7.56 ERA) for the Angels.

Dimers' best betting picks for Angels vs. Astros, plus game predictions and best odds, are detailed below.

Who will win Angels vs. Astros?

Based on trusted computer power and data, Dimers.com has simulated Wednesday's Angels-Astros MLB matchup 10,000 times.

Dimers' revolutionary predictive analytics model, DimersBOT, gives the Angels a 52% chance of getting the W against the Astros.

More: Free Betting Guide for Angels vs. Astros

Angels vs. Astros Current Odds

• Run Line: Astros +1.5 (-150), Angels -1.5 (+140)
• Moneyline: Astros +105, Angels -120
• Total: Over/Under 8.5 (-118/+110)

Run Line, Moneyline and Over/Under

The Astros are +1.5 underdogs against the Angels, with -150 at BetMGM the best odds currently available.

For the favored Angels (-1.5) to cover the run line, DraftKings Sportsbook has the best odds currently on offer at +140.

BetMGM currently has the best moneyline odds for the Astros at +105. That means you can bet $100 to profit $105, earning a total payout of $205, if they win.

Meanwhile, FanDuel Sportsbook currently has the best moneyline odds for the Angels at -120, where you can risk $120 to win $100, for a total payout of $220, if they come out on top.

The Over/Under is set at 8.5 with FanDuel Sportsbook, which currently has the best odds for the Over at -118, while Caesars Sportsbook currently has the best odds for the Under at +110.

As always, make sure you check the sportsbooks you have access to in your state for the best MLB odds and lines.

According to DimersBOT, the Astros (+1.5) are a 61% chance of covering the run line, while the 8.5-run Over/Under is a 53% chance of going Over.

More: Predictions for Every MLB Matchup

Best Bets for Angels vs. Astros

• Run Line: Astros +1.5 @ -150 via BetMGM (61% probability)
• Moneyline: Astros @ +105 via BetMGM
• Total: Under 8.5 @ +110 via Caesars Sportsbook

Dimers' best bets are based on complex simulations and betting intelligence to help you make smarter decisions with the legal sportsbooks in the USA.

While the Angels are more likely to win the game, according to DimersBOT, betting on the Astros moneyline is the best option due to the edge found when comparing our data-led probabilities to the sportsbooks' odds currently available.

Taking advantage of the edges published on Dimers is pivotal to achieving long-term profitability as a bettor.

Furthermore, despite the Over being more likely to hit on this occasion, Under 8.5 is our best bet on account of the better odds (+110) that are available from Caesars Sportsbook.

Angels vs. Astros Probabilities

Use our interactive widget below to view up-to-date Moneyline, Over/Under and Run Line probabilities and odds for LA Angels vs. Houston, and click or tap on See Matchup to reveal more.

Dimers has full betting coverage of Wednesday's Angels-Astros matchup, including pre-game predictions, free picks, and live win probabilities.

Don't forget, DimersBOT updates frequently, so check this article for the latest betting analysis before Angels vs. Astros on Wednesday April 20, 2022.

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All you need to do is click or tap on this exclusive FanDuel Sportsbook link and create an account – it's easy and takes less than 2 minutes.

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Angels vs. Astros 2022 Game Info

When do the Astros play the Angels?

• Date: Wednesday April 20, 2022
• Time: 6:40PM EDT / 3:40PM PDT
• Venue: Minute Maid Park

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What MLB games are on today?

The Angels and Astros aren't the only two MLB teams you can bet on today. DimersBOT never stops and we've got picks and top bets for every single MLB game via our MLB Predictions section.

Not only do we provide with you top-notch predictions, but we also have recommended bets for the Run Line, Over/Under and Moneyline. Sound good? Hell yeah it does!

While you're here, Dimers' Baseball Futures page is our in-house approach to revealing who will win the 2022 World Series, with our data-led probabilities matched against the best odds to win the World Series.