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American University vs. Virginia prediction: Virginia favored to win men's college basketball matchup [12/22/2025]

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Written by Mac Douglass

Get American University vs Virginia predictions for college basketball Monday.

American University-Virginia Predictions and Game Preview.
American University vs. Virginia men's college basketball prediction for Monday, December 22, 2025.

Virginia and American University will lock horns in men's college basketball action at John Paul Jones Arena on Monday, starting at 6:00 PM ET.

Based on updated simulation results, Dimers' advanced college basketball model projects Virginia as the most likely winner of the American University vs. Virginia game.

This article offers further insights into Monday's matchup, including an expanded look at the predicted score, best bets and picks.

American University vs. Virginia prediction: Who will win and cover?

Using innovative machine learning and statistical analysis, we have simulated the result of Monday's NCAA basketball matchup between American University and Virginia 10,000 times as part of our men's college basketball predictions coverage.

Our famous predictive model gives Virginia a 99% chance of beating American University. Our predicted final score has Virginia winning 89-61.

According to our model, the bookmakers have got it right, and American University and Virginia each have a 50% chance of covering the spread, while the 153.5-point over/under has a 54% chance of staying under.

 

American University vs. Virginia odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

Bet Type American University Virginia
Spread +27.5 (-105) -27.5 (-110)
Moneyline +4000 -6502
Total o153.5 (-112) u153.5 (-105)

All odds are correct at the time of publication and are subject to change.

American University vs. Virginia picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

Bet Type Pick Bet Now
Spread American University +27.5 -105
Moneyline Virginia -6502
Total Under 153.5 -105

According to our best men's college basketball bets, the top play to make on this game is Under 153.5 total points.

 

American University vs. Virginia game-day updates and essential details

Monday's men's college basketball game between Virginia and American University at John Paul Jones Arena is scheduled to commence at 6:00 PM ET.

  • Who: American University vs. Virginia
  • Date: Monday, December 22, 2025
  • Time: 6:00 PM ET/3:00PM PT
  • Venue: John Paul Jones Arena

Conclusion

We predict Virginia, with a 99% win probability, will likely beat American University on Monday.

AI and automation have enhanced this article to quickly deliver accurate American University vs. Virginia insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

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Written by
Mac Douglass
Senior Editor

Mac Douglass specializes in NFL previews for the NFC South and NFC East, MLB best bets, Formula 1 race previews, and professional tennis insights. Combining predictive simulations and data-driven sports analysis, Mac provides in-depth content to elevate the betting experience for sports fans.

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