American University vs. Virginia prediction: Virginia favored to win men's college basketball matchup [12/22/2025]

Virginia and American University will lock horns in men's college basketball action at John Paul Jones Arena on Monday, starting at 6:00 PM ET.

Based on updated simulation results, Dimers' advanced college basketball model projects Virginia as the most likely winner of the American University vs. Virginia game.

This article offers further insights into Monday's matchup, including an expanded look at the predicted score, best bets and picks.

American University vs. Virginia prediction: Who will win and cover?

Using innovative machine learning and data, we have simulated the result of Monday's NCAA basketball game between American University and Virginia 10,000 times as part of our men's college basketball predictions coverage.

Our leading predictive model gives Virginia a 98% chance of beating American University. Our predicted final score has Virginia winning 89-62.

According to our model, the bookmakers have got it right, and American University and Virginia each have a 50% chance of covering the spread, while the 154.5-point over/under has a 54% chance of staying under.

American University vs. Virginia odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

American University vs. Virginia picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: