49ers vs. Titans Predictions and Odds - Dec 23, 2021

The Tennessee Titans face the San Francisco 49ers in NFL Week 16 action at Nissan Stadium on Thursday, commencing at 8:20PM EST.

Dimers' top betting picks for 49ers vs. Titans, plus game predictions, best odds and player props, are detailed below.

Who will win 49ers vs. Titans?

Based on advanced machine learning and data, Dimers.com has simulated Thursday's 49ers-Titans NFL game 10,000 times.

Dimers' leading predictive analytics model, DimersBOT, gives the 49ers a 64% chance of getting the W against the Titans.

MORE: 49ers vs. Titans Simulated 10,000 Times

Point Spread, Moneyline and Over/Under

The Titans are +3 underdogs versus the 49ers, with -110 at BetMGM the best odds available.

For the favored 49ers (-3) to cover the spread, BetMGM also has the best odds on offer at -110.

DraftKings Sportsbook has the best moneyline odds for the Titans at +155. That means you can bet $100 to profit $155, earning a total payout of $255, if they win.

Elsewhere, BetMGM has the best moneyline odds for the 49ers at -164, where you can risk $164 to win $100, for a total payout of $264, if they come out on top.

The Over/Under sits at 45 with PointsBet, which has the best odds for the Over at -110, as well as the best odds for the Under at -110.

As always, check out the sportsbooks you have access to in your state for the best NFL odds and lines.

According to DimersBOT, the 49ers (-3) are a 52% chance of covering the spread, while the Over/Under total of 45 points is a 51% chance of going Over.

MORE: Predictions for Every NFL Week 16 Matchup

Best Bets for 49ers vs. Titans

• Spread: 49ers -3 at -110 with BetMGM (52% probability)
• Moneyline: 49ers Win at -164 with BetMGM (64% probability)
• Over/Under: Over 45 at -110 with PointsBet (51% probability)

49ers vs. Titans Score Prediction

Dimers.com's predicted final score for San Francisco vs. Tennessee at Nissan Stadium on Thursday has the 49ers winning 24-20.

Use our dynamic widget below to explore the latest Spread, Over/Under and Moneyline probabilities and odds for the game, and click or tap on See Matchup for more.

Dimers has full betting coverage of this week's 49ers-Titans matchup, including pre-game predictions, top betting picks, and live updates.

49ers vs. Titans Player Props

Who will score the first touchdown in 49ers vs. Titans? The data is in.

Featured below are the most likely first touchdown and most likely anytime touchdown scorers for both the 49ers and Titans, as well as projected player stats.

And you know what, we provide this information to you for FREE to help you select the best prop bets for Thursday's game.

According to DimersBOT, San Francisco's Deebo Samuel is most likely to score the first TD in 49ers vs. Titans.

DimersBOT gives Samuel a 14.7% chance of scoring the first TD at Nissan Stadium, while the 49ers WR is a 53.2% chance of reaching the end zone at any point in the game.

First Touchdown Scorer Probabilities

San Francisco 49ers

• Deebo Samuel: 14.7% probability
• Jeff Wilson: 10.5% probability
• George Kittle: 8.4% probability
• Brandon Aiyuk: 7.8% probability
• Jauan Jennings: 4.4% probability

Tennessee Titans

• A.J. Brown: 9.5% probability
• D'Onta Foreman: 7.7% probability
• Dontrell Hilliard: 5.2% probability
• Nick Westbrook-Ikhine: 4.0% probability
• Ryan Tannehill: 3.6% probability

Anytime Touchdown Scorer Probabilities

San Francisco 49ers

• Deebo Samuel: 53.2% probability
• Jeff Wilson: 43.0% probability
• George Kittle: 36.1% probability
• Brandon Aiyuk: 33.8% probability
• Jauan Jennings: 21.7% probability

Tennessee Titans

• A.J. Brown: 39.8% probability
• D'Onta Foreman: 34.7% probability
• Dontrell Hilliard: 25.2% probability
• Nick Westbrook-Ikhine: 18.0% probability
• Ryan Tannehill: 17.6% probability

Projected Box Score

Of the starting quarterbacks, the 49ers' Jimmy Garoppolo is projected to have a big game with 261 passing yards and 1.6 passing touchdowns. The Titans' Ryan Tannehill is expected to throw for 208 yards and 1.4 TDs.

49ers Starting QB

• Jimmy Garoppolo: 261 Passing Yards, 1.6 Passing TDs

Titans Starting QB

• Ryan Tannehill: 208 Passing Yards, 1.4 Passing TDs

49ers Rushing

• Jeff Wilson: 66 Rushing Yards, 0.5 TDs
• Deebo Samuel: 48 Rushing Yards, 0.4 TDs
• Jimmy Garoppolo: 9 Rushing Yards, 0.1 TDs

Titans Rushing

• D'Onta Foreman: 53 Rushing Yards, 0.3 TDs
• Dontrell Hilliard: 28 Rushing Yards, 0.2 TDs
• Jeremy McNichols: 17 Rushing Yards, 0.1 TDs

49ers Receiving

• George Kittle: 75 Receiving Yards, 0.4 TDs
• Deebo Samuel: 56 Receiving Yards, 0.3 TDs
• Brandon Aiyuk: 53 Receiving Yards, 0.3 TDs
• Jauan Jennings: 30 Receiving Yards, 0.2 TDs
• Trent Sherfield: 11 Receiving Yards, 0.1 TDs

Titans Receiving

• A.J. Brown: 65 Receiving Yards, 0.4 TDs
• Julio Jones: 27 Receiving Yards, 0.1 TDs
• Nick Westbrook-Ikhine: 23 Receiving Yards, 0.2 TDs
• Chester Rogers: 21 Receiving Yards, 0.1 TDs
• Dontrell Hilliard: 15 Receiving Yards, 0.1 TDs

Don't forget, DimersBOT updates often, so check this page for any changes to our betting analysis before 49ers vs. Titans on Thursday December 23, 2021.

Bet $10, Win $200 if 49ers or Titans Score a TD

BetMGM, the king of sportsbooks, is offering new customers the chance to Bet $10, Win $200 if the 49ers or Titans score a touchdown on Thursday.

That's right – bet 10 bucks and get 200 bucks in Free Bets if either team finds the end zone. It's that simple.

To take advantage of this promo, join BetMGM via this exclusive link, deposit $10+ and place, as your first real-money bet after opening your account, a single $10 pre-game, moneyline wager on San Francisco vs. Tennessee.

If either team scores a TD, you'll get $200 in Free Bets from BetMGM. How good is that!

Note: when you click or tap on a link on Dimers that leads to a third-party website that we have a commercial arrangement with (such as a sportsbook), we may earn a referral fee.

49ers vs. Titans 2021 Game Info

When do the Titans play the 49ers?

• Date: Thursday December 23, 2021
• Time: 8:20PM EST / 5:20PM PST
• Venue: Nissan Stadium

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