49ers vs. Jaguars Predictions and Odds - Nov 21, 2021

The Jacksonville Jaguars host the San Francisco 49ers in NFL Week 11 action at TIAA Bank Field on Sunday, starting at 1:00 PM EST.

Dimers' best betting picks for 49ers vs. Jaguars, as well as game predictions and best odds, are detailed in this article.

Who will win 49ers vs. Jaguars?

Based on cutting-edge machine learning and data, Dimers.com has simulated Sunday's 49ers-Jaguars matchup 10,000 times.

Dimers' popular predictive analytics model, DimersBOT, gives the 49ers a 72% chance of winning against the Jaguars.

MORE: 49ers vs. Jaguars simulated 10,000 times

49ers vs. Jaguars Point Spread, Moneyline and Over/Under

The Jaguars are +7 underdogs at home to the 49ers, with -110 at Caesars Sportsbook the best odds available.

For the favored 49ers (-7) to cover the spread, Caesars Sportsbook also has the best odds on offer at -110.

Caesars Sportsbook has the best moneyline odds for the Jaguars at +250. That means you can bet $100 to profit $250, earning a total payout of $350, if they win.

Elsewhere, FanDuel Sportsbook has the best moneyline odds for the 49ers at -270, where you can risk $270 to win $100, for a total payout of $370, if they come out on top.

The Over/Under for total points scored sits at 45 with Caesars Sportsbook, which has the best odds for the Over at -110, as well as the best odds for the Under at -110.

As always, check out the sportsbooks you can bet with in your state for the best NFL odds and lines.

According to DimersBOT, the Jaguars (+7) are a 57% chance of covering the spread, while the 45-point Over/Under is a 51% chance of going Over.

MORE: Best bets today for all major US and international sports

Best Bets for 49ers vs. Jaguars

• Spread: Jaguars +7 at -110 with Caesars Sportsbook (57% probability) 🔥
• Moneyline: Jaguars Win at +250 with Caesars Sportsbook
• Over/Under: Over 45 at -110 with Caesars Sportsbook (51% probability)

If you see a 🔥, that means it's one of Dimers' best free picks today across all sports.

While the 49ers are more likely to win the game, according to DimersBOT, betting on the Jaguars moneyline is the best option due to the edge identified when comparing our data-led probabilities to the sportsbooks' odds.

Taking advantage of the edges published here at Dimers.com is pivotal to achieving long-term profitability as a bettor.

49ers vs. Jaguars Score Prediction

Dimers.com's predicted final score for San Francisco vs. Jacksonville at TIAA Bank Field this Sunday has the 49ers prevailing 25-19.

Dimers has full coverage of this week's 49ers-Jaguars game, including pre-game predictions, free picks, and live win probabilities.

Don't forget, DimersBOT updates frequently, so check this article for any changes ahead of 49ers vs. Jaguars on Sunday November 21, 2021.

49ers vs. Jaguars 2021 Game Info

When do the Jaguars play the 49ers?

• Date: Sunday November 21, 2021
• Time: 1:00 PM EST / 10:00 AM PST
• Venue: TIAA Bank Field

Looking to join an online sportsbook and start betting on the NFL? Check out the top sports betting promos in your state.

Want more NFL previews like this?

So, you liked our 49ers vs. Jaguars betting preview? Awesome. Did you know our NFL Betting News section has a detailed betting preview for every NFL game the second the sportsbooks release their odds?

That's right, our predictive analytics model then compares those odds against its own probabilities to find value in the markets. This allows us to produce the most authoritative NFL betting previews and beat the public and the sportsbooks to the punch.

It's only a click away, so why not take a look around?