May 22, 2026
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Read Article Rays vs. Yankees prediction: Yankees favored to win Friday's MLB matchup [5/22/2026]
Updated: | First published:
Written by Jason Bevilacqua, Head of Content and Communities
Get Tampa Bay Rays vs New York Yankees predictions for MLB Friday.
The New York Yankees will square off with the Tampa Bay Rays in MLB action at Yankee Stadium on Friday, beginning at 7:05 PM ET.
Gerrit Cole (0-0, 0.00 ERA) will start on the mound for the Yankees, pitting him against Nick Martinez (4-1, 1.51 ERA) for the Rays.
Based on the latest simulations, Dimers' advanced MLB model predicts the Yankees as the most likely winner of the Rays vs. Yankees game.
This article offers a closer look at Friday's matchup, including best bets and picks.
Rays vs. Yankees prediction: Who will win and cover?
Using trusted machine learning and statistical analysis, we have simulated the outcome of Friday's MLB game between the Rays and Yankees, forming part of our MLB predictions coverage.
Our independent predictive model gives the Yankees a 59% chance of defeating the Rays.
According to our model, the Rays (+1.5) have a 58% chance of covering the run line, while the 8-run over/under has a 52% chance of going over.
Rays vs. Yankees odds [5/22/2026]
We have researched the best MLB odds in America for this game, which are listed here:
| Bet Type | Rays | Yankees |
|---|---|---|
| Run Line | +1.5 (-164) | -1.5 (+141) |
| Moneyline | +130 | -149 |
| Total | o8 (-102) | u8 (-118) |
All odds are correct at the time of publication and are subject to change.
Rays vs. Yankees picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Yankees -1.5 | +141 |
| Moneyline | Yankees | -149 |
| Total | Over 8 | -102 |
According to our best MLB bets, the top play to make on this game is Over 8 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Rays vs. Yankees game-day updates and essential details
Friday's MLB action between the Yankees and Rays at Yankee Stadium is scheduled to start at 7:05 PM ET.
- Who: Tampa Bay Rays vs. New York Yankees
- Date: Friday, May 22, 2026
- Time: 7:05 PM ET/4:05PM PT
- Venue: Yankee Stadium
Conclusion
We predict the Yankees, with a 59% win probability, will likely beat the Rays in Friday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
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Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.
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