Cardinals vs. Nationals Prediction: Close Contest Projected After New Data Released for Saturday's MLB Matchup [5/10/2025]

The Washington Nationals and St. Louis Cardinals are scheduled to meet in MLB action at Nationals Park on Saturday, starting at 4:05PM ET.

Trevor Williams (2-3, 5.86 ERA) will get the ball for the Nationals, up against Andre Pallante (2-2, 4.75 ERA) for the Cardinals.

Based on the latest simulations, Dimers' proven MLB model (see Dimers Pro for full access) projects an equal chance for both the Nationals and Cardinals to win today's game.

"Our team has used the latest data to run 10,000 simulations of Saturday's St. Louis-Washington game," said Dimers' Chief Content Officer, Nick Slade.

"Based on the latest updates and extensive data, we predict a 50-50 chance for both the Nationals and Cardinals, making it a highly competitive matchup."

For expanded analysis of Saturday's matchup, including best bets and picks, visit our interactive Cardinals vs. Nationals predictions page.

Nationals vs. Cardinals Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and data, we have simulated the outcome of Saturday's MLB game between the Cardinals and Nationals 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently can't split the two teams, giving both the Cardinals and Nationals a 50% chance of winning the game.

According to our model, the Nationals (+1.5) have a 63% chance of covering the run line, while the over/under total of 9 runs has a 51% chance of going over.

Cardinals vs. Nationals Odds [5/10/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Cardinals	Nationals
Run Line	-1.5 (+146)	+1.5 (-170)
Moneyline	-112	-104
Total	o9 (-118)	u9 (+100)

All odds are correct at the time of publication and are subject to change.

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Cardinals vs. Nationals Picks and Best Bets

Our model's biggest edge in today's Cardinals vs. Nationals matchup is on the total.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free ⚾️ Picks

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.

Cardinals vs. Nationals Game-Day Updates and Essential Details

Saturday's MLB action between the Nationals and Cardinals at Nationals Park is scheduled to start at 4:05PM ET.

• Who: St. Louis Cardinals vs. Washington Nationals
• Date: Saturday, May 10, 2025
• Time: 4:05PM ET/1:05PM PT
• Venue: Nationals Park

Dimers.com's comprehensive preview of Saturday's Cardinals vs. Nationals matchup includes our prediction, picks and the latest betting odds.

Before making any St. Louis vs. Washington picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

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Conclusion

We predict a close game between the Cardinals and Nationals on Saturday, with each team having a 50% chance of winning.

AI and automation have enhanced this article to quickly deliver accurate Cardinals vs. Nationals insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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