Cardinals vs. Cubs Prediction: Cubs Predicted to Win Friday's MLB Matchup [7/4/2025]

The Chicago Cubs will face the St. Louis Cardinals in MLB action at Wrigley Field on Friday, starting at 2:20PM ET.

Colin Rea (5-3, 4.37 ERA) will be on the bump for the Cubs, while the Cardinals will counter with Miles Mikolas (4-5, 4.76 ERA).

Based on the latest simulations, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Cubs as the most likely winner of today's game.

For a closer look at Friday's matchup, including best bets and picks, visit our interactive Cardinals vs. Cubs predictions page.

Cubs vs. Cardinals Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and statistical analysis, we have simulated the outcome of Friday's MLB matchup between the Cardinals and Cubs 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently gives the Cubs a 56% chance of defeating the Cardinals.

According to our model, the Cardinals (+1.5) have a 61% chance of covering the run line, while the over/under total of 9.5 runs has a 53% chance of staying under.

Cardinals vs. Cubs Odds [7/4/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Cardinals	Cubs
Run Line	+1.5 (-154)	-1.5 (+140)
Moneyline	+130	-142
Total	o9.5 (+100)	u9.5 (-118)

All odds are correct at the time of publication and are subject to change.

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Cardinals vs. Cubs Picks and Best Bets

Our model's biggest edge in today's Cardinals vs. Cubs matchup is on the moneyline.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.

Cardinals vs. Cubs Game-Day Updates and Essential Details

Friday's MLB game between the Cubs and Cardinals at Wrigley Field is scheduled to start at 2:20PM ET.

• Who: St. Louis Cardinals vs. Chicago Cubs
• Date: Friday, July 4, 2025
• Time: 2:20PM ET/11:20AM PT
• Venue: Wrigley Field

Dimers.com's comprehensive preview of Friday's Cardinals vs. Cubs matchup includes our prediction, picks and the latest betting odds.

Before making any Cardinals vs. Cubs picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Cubs, with a 56% win probability, will likely beat the Cardinals on Friday.

AI and automation have enhanced this article to quickly deliver accurate Cardinals vs. Cubs insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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