Padres vs. Pirates Prediction: Pittsburgh Predicted to Win Sunday's MLB Matchup [5/4/2025]

The Pittsburgh Pirates and San Diego Padres will meet in MLB action at PNC Park on Sunday, starting at 1:35PM ET.

The Pirates will send Andrew Heaney (2-2, 2.50 ERA) to the mound, while the Padres will counter with Stephen Kolek (0-0, 0.00 ERA).

Based on the latest simulations, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Pirates as the most likely winner of today's game.

"Using the most recent data, our experts ran 10,000 simulations of Sunday's San Diego-Pittsburgh game," said Dimers' Chief Content Officer, Nick Slade.

"After accounting for recent updates and other variables, our prediction shows the Pirates with a win probability of 51%, while the Padres have 49%."

For a closer look at Sunday's matchup, including best bets and picks, visit our interactive Padres vs. Pirates predictions page.

Pirates vs. Padres Prediction: Who Will Win?

Using trusted machine learning and data analysis, we have simulated the result of Sunday's MLB matchup between the Padres and Pirates 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Pirates a 51% chance of beating the Padres.

According to our model, the 9-run over/under has a 57% chance of staying under.

Padres vs. Pirates Odds [5/4/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Padres	Pirates
Moneyline	-108	-108
Total	o9 (+100)	u9 (-112)

All odds are correct at the time of publication and are subject to change.

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Padres vs. Pirates Picks and Best Bets

Our model's biggest edge in today's Padres vs. Pirates matchup is on the moneyline.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets

Calling Our Shot produces daily MLB betting content, including the latest free picks featured below.

Padres vs. Pirates Game-Day Updates and Essential Details

Sunday's MLB game between the Pirates and Padres at PNC Park is scheduled to start at 1:35PM ET.

• Who: San Diego Padres vs. Pittsburgh Pirates
• Date: Sunday, May 4, 2025
• Time: 1:35PM ET/10:35AM PT
• Venue: PNC Park

Dimers.com's in-depth preview of Sunday's Padres vs. Pirates matchup includes our prediction, picks and the latest betting odds.

Before making any San Diego vs. Pittsburgh picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

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Conclusion

We predict the Pirates, with a 51% win probability, will likely beat the Padres on Sunday.

AI and automation have enhanced this article to quickly deliver accurate Padres vs. Pirates insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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