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Read Article Padres vs. Brewers prediction: Why Milwaukee is favored to win Wednesday's MLB matchup [5/13/2026]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get San Diego Padres vs Milwaukee Brewers predictions for MLB Wednesday.
The Milwaukee Brewers and San Diego Padres will meet in MLB action at American Family Field on Wednesday, starting at 7:40 PM ET.
The Brewers will start Jacob Misiorowski (3-2, 2.46 ERA), while the Padres are going with Michael King (3-2, 2.76 ERA).
Based on updated simulation results, Dimers' advanced MLB model projects the Brewers as the most likely winner of the Padres vs. Brewers game.
This article offers a closer look at Wednesday's matchup, including best bets and picks.
Padres vs. Brewers prediction: Who will win and cover?
Using trusted machine learning and statistical analysis, we have simulated the outcome of Wednesday's MLB game between the Padres and Brewers, forming part of our MLB predictions coverage.
Our famous predictive model currently gives the Brewers a 57% chance of defeating the Padres.
According to our model, the Padres (+1.5) have a 62% chance of covering the run line, while the 7-run over/under has a 52% chance of going over.
Padres vs. Brewers odds [5/13/2026]
We have sourced the best MLB odds in America for this game, which are listed here:
| Bet Type | Padres | Brewers |
|---|---|---|
| Run Line | +1.5 (-164) | -1.5 (+140) |
| Moneyline | +140 | -156 |
| Total | o7 (-102) | u7 (-120) |
All odds are correct at the time of publication and are subject to change.
Padres vs. Brewers picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Padres +1.5 | -164 |
| Moneyline | Padres | +140 |
| Total | Over 7 | -102 |
According to our MLB best bets, the top play to make on this game is Over 7 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Padres vs. Brewers game-day updates and essential details
Wednesday's MLB game between the Brewers and Padres at American Family Field is scheduled to commence at 7:40 PM ET.
- Who: San Diego Padres vs. Milwaukee Brewers
- Date: Wednesday, May 13, 2026
- Time: 7:40 PM ET/4:40PM PT
- Venue: American Family Field
Conclusion
We predict the Brewers, with a 57% win probability, will likely beat the Padres in Wednesday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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