Padres vs. Cubs prediction: Why Cubs are favored to win Monday's MLB matchup [6/29/2026]
Get San Diego Padres vs Chicago Cubs predictions for MLB Monday.
The Chicago Cubs and San Diego Padres are scheduled to meet in MLB action at Wrigley Field on Monday, starting at 8:05 PM ET.
The Cubs will have Shota Imanaga (5-6, 4.40 ERA) as their starting pitcher, while the Padres have opted for Griffin Canning (1-5, 7.38 ERA).
Based on the latest simulation results, Dimers' proven MLB model predicts the Cubs as the most likely winner of the Padres vs. Cubs game.
This article offers an expanded analysis of Monday's matchup, including best bets and picks.
Padres vs. Cubs prediction: Who will win and cover?
Our famous predictive model gives the Cubs a 57.6% chance of defeating the Padres.
According to our model, the Padres (+1.5) have a 57.7% chance of covering the run line, while the over/under total of 11.5 runs has a 52.8% chance of staying under,.
Padres vs. Cubs odds [6/29/2026]
We have sourced the best MLB odds in America for this game, which are listed here:
| Bet Type | Padres | Cubs |
|---|---|---|
| Run Line | +1.5 (-138) | -1.5 (+122) |
| Moneyline | +135 | -158 |
| Total | o11.5 (+100) | u11.5 (-116) |
All odds are correct at the time of publication and are subject to change.
Padres vs. Cubs picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Padres +1.5 | -138 |
| Moneyline | Padres | +135 |
| Total | Under 11.5 | -116 |
According to our MLB best bets, the top play to make on this game is Padres to win.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Padres vs. Cubs game-day updates and essential details
Monday's MLB game between the Cubs and Padres at Wrigley Field is scheduled to start at 8:05 PM ET.
- Who: San Diego Padres vs. Chicago Cubs
- Date: Monday, June 29, 2026
- Time: 8:05 PM ET/5:05PM PT
- Venue: Wrigley Field
Conclusion
We predict the Cubs, with a 57.6% win probability, will likely beat the Padres in Monday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
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Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
