Spurs vs. Lakers prediction: Lakers to win, Luka Doncic projected for 31 points in Wednesday's NBA game [11/5/2025]

The Los Angeles Lakers and San Antonio Spurs will lock horns in NBA action at Crypto.com Arena on Wednesday, with tipoff at 10:00PM ET.

Based on updated simulation results and today’s injury news, Dimers' advanced NBA model predicts the Lakers as the most likely winner of the Spurs vs. Lakers game.

This prediction follows the latest NBA Injury Report, which suggests the Lakers lineup will feature players like Luka Doncic, Austin Reaves and Rui Hachimura, while the Spurs will look to Victor Wembanyama, Stephon Castle and Devin Vassell.

LeBron James will not be on the court, with the superstar out for this one.

This article offers a closer look at Wednesday's matchup, including an expanded look at the predicted score, best bets and player prop picks.

Spurs vs. Lakers prediction: Who will win, cover the spread?

Using powerful machine learning and data, we have simulated the outcome of Wednesday's NBA matchup between the Spurs and Lakers 10,000 times as part of our NBA predictions coverage.

Our leading predictive model gives the Lakers a 61% chance of defeating the Spurs. Our predicted final score has the Lakers winning 114-111.

According to our model, the Lakers (-3) have a 52% chance of covering the spread, while the 227.5-point over/under has a 51% chance of staying under.

Spurs vs. Lakers odds

We have researched the best NBA odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Spurs vs. Lakers picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our NBA best bets, the top play to make on this game is Lakers to win.

Spurs vs. Lakers player props

NBA player props are a great way to wager on Wednesday's Spurs vs. Lakers matchup without necessarily betting on the outcome. We have crunched the numbers to project how each team's leading players will perform at Crypto.com Arena.

Victor Wembanyama is expected to lead the Spurs with 28 points, 11 rebounds and 4 assists, while Luka Doncic is projected to have 31 points, 9 rebounds and 8 assists for the Lakers.

Check out our NBA player projections for a full range of projected box scores, including points, assists, rebounds and more, for every game this season.

Spurs prediction

Our model's projected player stats for the Spurs are:

Lakers prediction

Projected points, rebounds, assists and three-pointers made for the Lakers:

Spurs vs. Lakers game-day updates and essential details

Wednesday's action between the Lakers and Spurs at Crypto.com Arena is scheduled to begin at 10:00PM ET.

• Who: San Antonio Spurs vs. Los Angeles Lakers
• Date: Wednesday, November 5, 2025
• Time: 10:00PM ET/7:00PM PT
• Venue: Crypto.com Arena

Conclusion

We predict the Lakers, with a 61% win probability, will likely beat the Spurs on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Spurs vs. Lakers insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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