Spurs vs. Mavericks prediction: Dallas favored to win Wednesday's NBA matchup [10/22/2025]

The Dallas Mavericks and San Antonio Spurs will meet in NBA action at American Airlines Center on Wednesday, starting at 9:30PM ET.

Based on the latest simulations and today’s injury news, Dimers' advanced NBA model projects the Mavericks as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Spurs-Mavericks game 10,000 times," said Damien Souness from Dimers.

"With the latest updates and numerous other variables, we estimate the Mavericks' chance of winning at 63%, with the Spurs at 37%."

This prediction follows the latest NBA Injury Report, which suggests the Mavericks lineup will feature stars like Anthony Davis, Cooper Flagg and P.J. Washington, while the Spurs will be led by Victor Wembanyama, Stephon Castle and Devin Vassell.

For a closer look at Wednesday's matchup, including an expanded look at the predicted score, best bets and player prop picks, visit our interactive Spurs vs. Mavericks predictions page.

Spurs vs. Mavs prediction: Who will win, cover the spread?

Using innovative machine learning and statistical analysis, we have simulated the result of Wednesday's NBA game between the Spurs and Mavericks 10,000 times as part of our NBA predictions coverage.

Our independent predictive model currently gives the Mavericks a 63% chance of beating the Spurs. Our predicted final score has the Mavericks winning 113-109.

According to our model, the Mavericks (-4.5) have a 53% chance of covering the spread, while the over/under total of 223.5 points has a 51% chance of staying under.

Spurs vs. Mavericks odds

We have sourced the best NBA odds in America for this game, which are listed here:

Bet Type	Spurs	Mavericks
Spread	+4.5 (-125)	-4.5 (+105)
Moneyline	+142	-160
Total	o223.5 (-115)	u223.5 (-105)

All odds are correct at the time of publication and are subject to change.

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Spurs vs. Mavericks picks and best bets

Our model's biggest edge in today's Spurs vs. Mavericks matchup is on the over/under.

Our expert predictions, matched against the best odds, reveal the best NBA picks and NBA best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Spurs vs. Mavericks player props

NBA player props are an exciting way to wager on the San Antonio vs. Dallas game without necessarily betting on the outcome. We have crunched the numbers to project how each team's leading players will perform at American Airlines Center.

Victor Wembanyama is expected to lead the Spurs in scoring, while Anthony Davis is projected to be the top scorer for the Mavericks.

Dimers Pro users can access a full range of player props and projected box scores, including points, assists, rebounds and more, for every NBA game this season.

Spurs vs. Mavs game-day updates and essential details

Wednesday's game between the Mavericks and Spurs at American Airlines Center is scheduled to start at 9:30PM ET.

• Who: San Antonio Spurs vs. Dallas Mavericks
• Date: Wednesday, October 22, 2025
• Time: 9:30PM ET/6:30PM PT
• Venue: American Airlines Center

Dimers' full preview of Wednesday's Spurs vs. Mavericks matchup includes our prediction, picks and the latest betting odds.

Before making any Spurs vs. Mavs picks, be sure to check out the latest NBA predictions and betting advice from Dimers Pro.

Conclusion

We predict the Mavericks, with a 63% win probability, will likely beat the Spurs on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Spurs vs. Mavericks insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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