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Pirates vs. Diamondbacks prediction: Why Arizona is favored to win Tuesday's MLB matchup [5/5/2026]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get Pittsburgh Pirates vs Arizona Diamondbacks predictions for MLB Tuesday.
MLB action continues on Tuesday at 9:40 PM ET as the Pittsburgh Pirates square off with the Arizona Diamondbacks at Chase Field.
Eduardo Rodriguez (2-0, 3.03 ERA) will be on the bump for the Diamondbacks, while the Pirates are going with Bubba Chandler (1-3, 4.97 ERA).
Based on updated simulations, Dimers' proven MLB model projects the Diamondbacks as the most likely winner of the Pirates vs. Diamondbacks game.
This article offers an expanded analysis of Tuesday's matchup, including best bets and picks.
Pirates vs. Diamondbacks prediction: Who will win and cover?
Using innovative machine learning and data, we have simulated the result of Tuesday's MLB game between the Pirates and Diamondbacks, forming part of our MLB predictions coverage.
Our famous predictive model gives the Diamondbacks a 57% chance of defeating the Pirates.
According to our model, the Pirates (+1.5) have a 60% chance of covering the run line, while the over/under total of nine runs has a 56% chance of going over.
Pirates vs. Diamondbacks odds [5/5/2026]
We have sourced the best MLB odds in America for this game, which are listed here:
| Bet Type | Pirates | Diamondbacks |
|---|---|---|
| Run Line | +1.5 (-181) | -1.5 (+160) |
| Moneyline | +115 | -134 |
| Total | o9 (-110) | u9 (-110) |
All odds are correct at the time of publication and are subject to change.
Pirates vs. Diamondbacks picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Diamondbacks -1.5 | +160 |
| Moneyline | Diamondbacks | -134 |
| Total | Over 9 | -110 |
According to our MLB best bets, the top play to make on this game is Over 9 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Pirates vs. Diamondbacks game-day updates and essential details
Tuesday's MLB game between the Diamondbacks and Pirates at Chase Field is scheduled to commence at 9:40 PM ET.
- Who: Pittsburgh Pirates vs. Arizona Diamondbacks
- Date: Tuesday, May 5, 2026
- Time: 9:40 PM ET/6:40PM PT
- Venue: Chase Field
Conclusion
We predict the Diamondbacks, with a 57% win probability, will likely beat the Pirates in Tuesday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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