76ers vs. Pistons prediction: Detroit favored to win Friday's NBA Cup matchup [11/14/2025]

NBA Cup action continues on Friday at 7:30PM ET as the Philadelphia 76ers take on the Detroit Pistons at Little Caesars Arena.

Based on updated simulation results and today’s injury reports, Dimers' proven NBA model gives the Pistons a slight edge with a 52% win probability over the 76ers.

This prediction follows the latest NBA Injury Report, which suggests the Pistons lineup will feature players like Daniss Jenkins, Duncan Robinson and Caris LeVert, while the 76ers will be led by Tyrese Maxey, Quentin Grimes and Kelly Oubre.

This article offers an expanded analysis of Friday's 76ers vs. Pistons matchup, including an expanded look at the predicted score, best bets and player prop picks.

Sixers vs. Sixers prediction: Who will win NBA Cup game?

As part of Dimers' NBA predictions coverage—and following a review of recent results—our pregame model has generated moneyline, spread, and over/under probabilities for Friday's clash between the 76ers and Pistons.

According to our model, the 76ers (-1) have a 53% chance of covering the spread, while the over/under total of 229.5 points has a 52% chance of staying under.

While there is no way for an NBA game to end in a tie, our prediction of 114-114 is based on each team's average score in the above-mentioned simulations of Sixers vs. Pistons.

76ers vs. Pistons odds

We have sourced the best NBA odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

76ers vs. Pistons picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our best NBA bets for Friday, the top play to make on this game is Pistons to win.

76ers vs. Pistons player props

Looking for Philadelphia vs. Detroit NBA prop bets? We have crunched the numbers to project how each team's leading players will perform at Little Caesars Arena.

Tyrese Maxey is expected to lead the 76ers with 28 points, 4 rebounds and 6 assists, while Daniss Jenkins is projected to have 17 points, 4 rebounds and 6 assists for the Pistons.

Check out our NBA player projections for a full range of projected box scores, including points, assists, rebounds and more, for every game this season.

76ers prediction

Our model's projected player stats for the 76ers are:

Pistons prediction

Projected points, rebounds, assists and three-pointers made for the Pistons:

Sixers vs. Pistons game-day updates and essential details

Friday's game between the Pistons and 76ers at Little Caesars Arena is scheduled to start at 7:30PM ET.

• Who: Philadelphia 76ers vs. Detroit Pistons
• Date: Friday, November 14, 2025
• Time: 7:30PM ET/4:30PM PT
• Venue: Little Caesars Arena
• Tournament details: 2025 Emirates NBA Cup

Conclusion

We predict the Pistons, with a 52% win probability, will likely beat the 76ers on Friday, with Tyrese Maxey projected for a game-high 49 fantasy points.

AI and automation have enhanced this article to quickly deliver accurate 76ers vs. Pistons insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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