NBA picks today: Wednesday's best bets include two moneyline plays [10/22/2025]

Today’s NBA picks for October 22, 2025 are here, with Wednesday’s NBA best bets fueled by thousands of predictive simulations analyzing the latest odds and matchups.

These NBA best bets include matchups like Timberwolves vs. Trail Blazers and Spurs vs. Mavericks, with this article updated throughout the day to feature the highest-probability plays based on thousands of data-driven simulations from our predictive analytics model.

But if you're serious about long-term profit, it's not just about probability—it's about edge. To unlock our highest-edge NBA bets—the ones with true long-term value—join Dimers Pro.

Pro members get unlimited access to everything Dimers has to offer on Wednesday, October 22, 2025, including our full set of picks and best bets for today and the week ahead.

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List of NBA picks tonight [10/22, updated 9:01PM ET]

After diving deep into the numbers and running thousands of simulations, our famous predictive analytics model has identified the best basketball bets for Wednesday, October 22, 2025.

Timberwolves ML (-178)

• Probability: 66.3%
• Edge: 2.3%
• Matchup: Timberwolves vs. Trail Blazers (10:00PM ET, Wednesday)

Drawing from our Timberwolves vs Trail Blazers prediction, our model has pinpointed a high-probability NBA betting opportunity tonight, which comes in the Timberwolves vs. Trail Blazers game. We recommend a bet on the Timberwolves ML at -178 odds, with our analysis showing a 66.3% chance of hitting and a compelling edge of 2.3%.

Mavericks ML (-160)

• Probability: 64.5%
• Edge: 3.0%
• Matchup: Spurs vs. Mavericks (9:30PM ET, Wednesday)

Based on our Spurs vs Mavericks prediction, our model has found another strong NBA bet for Wednesday's basketball action, this time in the game between the Spurs and Mavericks. We suggest placing a wager on Mavericks ML at -160 odds, with a 64.5% probability delivering a 3.0% edge.

NBA best bets: Wednesday, 10/22/2025

As of 9:01PM ET, here are our top two NBA bets by probability recommended by our model:

Matchup	Bet	Odds	Probability	Edge
Timberwolves vs. Trail Blazers	Timberwolves ML	-178 @ FanDuel	66.3%	2.3%
Spurs vs. Mavericks	Mavericks ML	-160 @ BetMGM	64.5%	3.0%

Dimers Pro unlocks instant access to the most valuable bets across all sports, powered by our advanced predictive model.

Today, Dimers Pro subscribers have access to two NBA picks—with access to all of these being what makes a difference over time.

Join Dimers Pro now to access these picks, as well as a comprehensive range of props, trends and parlays for October 22, 2025.

More NBA Betting Guides

This article is part of our NBA player props and NBA best bets series. For related content on October 22, check out:

• Wednesday's NBA First Basket Predictions
• NBA Player Prop Picks for Wednesday

List of upcoming NBA games to bet on [10/22/2025]

• Spurs vs. Mavericks (9:30PM ET, Wednesday)
• Timberwolves vs. Trail Blazers (10:00PM ET, Wednesday)
• Kings vs. Suns (10:00PM ET, Wednesday)
• Thunder vs. Pacers (7:30PM ET, Thursday)

More about NBA

For more NBA betting content, we have NBA trends for every game, as well as daily NBA betting news and the latest NBA title odds and predictions.

Conclusion

Our NBA best bets are locked and loaded for October 22, 2025, featuring plays such as Timberwolves ML and Mavericks ML. Powered by advanced simulations, these picks are here to boost your betting game.

This article, enhanced by AI and automation, aims to deliver accurate NBA insights quickly, with human oversight ensuring high editorial quality. Our predictions are based on current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

All odds and probabilities in this article are correct and accurate at the time of publication.

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