Michigan State vs. Kentucky prediction: Kentucky favored to win men's college basketball matchup [11/18/2025]

Kentucky and Michigan State will meet in men's college basketball action at Madison Square Garden on Tuesday, with tipoff at 6:30PM ET.

Based on the latest simulations, Dimers' proven college basketball model projects Kentucky as the most likely winner of the Michigan State vs. Kentucky game.

This article offers further insights into Tuesday's matchup, including an expanded look at the predicted score, best bets and picks.

Michigan State vs. Kentucky prediction: Who will win and cover?

Using innovative machine learning and data analysis, we have simulated the result of Tuesday's NCAA basketball matchup between Michigan State and Kentucky 10,000 times as part of our men's college basketball predictions coverage.

Our leading predictive model gives Kentucky a 72% chance of beating Michigan State. Our predicted final score has Kentucky winning 79-73.

According to our model, Kentucky (-4.5) has a 60% chance of covering the spread, while the over/under total of 153.5 points has an equal 50-50 chance of hitting.

Michigan State vs. Kentucky odds

We have sourced the best Men's College Basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Michigan State vs. Kentucky picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our men's college basketball best bets, the top play to make on this game is Kentucky -4.5 at the spread.

Michigan State vs. Kentucky game-day updates and essential details

Tuesday's men's college basketball action between Kentucky and Michigan State at Madison Square Garden is scheduled to commence at 6:30PM ET.

• Who: Michigan State vs. Kentucky
• Date: Tuesday, November 18, 2025
• Time: 6:30PM ET/3:30PM PT
• Venue: Madison Square Garden

Conclusion

We predict Kentucky, with a 72% win probability, will likely beat Michigan State on Tuesday.

AI and automation have enhanced this article to quickly deliver accurate Michigan State vs. Kentucky insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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