Michigan vs. Arizona prediction: Why Arizona is favored to win men's March Madness Final Four matchup [4/4/2026]

Arizona and Michigan will lock horns in March Madness Final Four action at Lucas Oil Stadium on Saturday, starting at 8:54 PM ET.

For this Final Four clash, Michigan—the first Big Ten team in 50 years to go 10–0 on the road in conference play— take on Arizona, a complete team with a monstrous frontcourt and NBA-level talent.

Based on updated simulation results, Dimers' advanced college basketball model predicts Arizona as the most likely winner of the Michigan vs. Arizona game.

This article offers further insights into Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

Michigan vs. Arizona prediction: Who will win and advance to the Championship Game?

Using innovative machine learning and data, we have simulated the outcome of Saturday's NCAAM Tournament game between Michigan and Arizona, forming part of today's college basketball picks coverage.

Our leading predictive model gives Arizona a 55% chance of beating Michigan. Our predicted final score has Arizona winning 79-78.

According to our model, Arizona (+1.5) has a 56% chance of covering the spread, while the 157.5-point over/under has a 52% chance of going over.

Michigan vs. Arizona odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Michigan vs. Arizona picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: