Grizzlies vs. Cavaliers prediction: Cleveland to win, Donovan Mitchell projected for big game in Saturday's NBA matchup [11/15/2025]

NBA action continues on Saturday at 5:00PM ET as the Memphis Grizzlies lock horns with the Cleveland Cavaliers at Rocket Arena.

Based on the latest simulation results and today’s injury updates, Dimers' proven NBA model predicts the Cavaliers as the most likely winner of the Grizzlies vs. Cavaliers game.

This prediction follows the latest NBA Injury Report, which suggests the Cavaliers lineup will feature stars like Donovan Mitchell, Evan Mobley and De'Andre Hunter, while the Grizzlies will be led by Ja Morant, Jaren Jackson and Santi Aldama.

This article offers an expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and player prop picks.

Grizzlies vs. Cavs prediction: Who will win and cover?

As part of Dimers' NBA predictions coverage—and following a review of recent results—our pregame model has generated moneyline, spread, and over/under probabilities for Saturday's clash between the Grizzlies and Cavaliers.

According to our model, the Grizzlies (+10.5) have a 56% chance of covering the spread, while the over/under total of 241.5 points has a 52% chance of staying under.

Grizzlies vs. Cavaliers odds

We have researched the best NBA odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Grizzlies vs. Cavaliers picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our best NBA bets for Saturday, the top play to make on this game is Grizzlies +10.5 at the spread.

Grizzlies vs. Cavaliers player props

Betting on Grizzlies vs. Cavaliers NBA prop bets? We use the best information available to project how each team's leading players will perform at Rocket Arena.

Ja Morant is expected to lead the Grizzlies with 21 points, 4 rebounds and 8 assists, while Donovan Mitchell is projected to have 28 points, 5 rebounds and 6 assists for the Cavaliers.

Check out our NBA player projections for a full range of projected box scores, including points, assists, rebounds and more, for every game this season.

Grizzlies prediction

Our model's projected player stats for the Grizzlies are:

Cavaliers prediction

Projected points, rebounds, assists and three-pointers made for the Cavaliers:

Grizzlies vs. Cavs game-day updates and essential details

Saturday's game between the Cavaliers and Grizzlies at Rocket Arena is scheduled to start at 5:00PM ET.

• Who: Memphis Grizzlies vs. Cleveland Cavaliers
• Date: Saturday, November 15, 2025
• Time: 5:00PM ET/2:00PM PT
• Venue: Rocket Arena

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Conclusion

We predict the Cavaliers, with a 78% win probability, will likely beat the Grizzlies on Saturday, with Donovan Mitchell projected for a game-high 50 fantasy points.

AI and automation have enhanced this article to quickly deliver accurate Grizzlies vs. Cavaliers insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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