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Louisville vs. Tennessee prediction: Why Tennessee is favored to win men's college basketball matchup [12/16/2025]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get Louisville vs Tennessee predictions for college basketball Tuesday.
Tennessee and Louisville will lock horns in men's college basketball action at Thompson-Boling Arena on Tuesday, starting at 7:00 PM ET.
Based on updated simulations, Dimers' proven college basketball model predicts Tennessee as the most likely winner of the Louisville vs. Tennessee game.
This article offers a closer look at Tuesday's matchup, including an expanded look at the predicted score, best bets and picks.
Louisville vs. Tennessee prediction: Who will win and cover?
Using trusted machine learning and data, we have simulated the result of Tuesday's NCAA basketball matchup between Louisville and Tennessee 10,000 times as part of our men's college basketball predictions coverage.
Our leading predictive model currently gives Tennessee a 63% chance of beating Louisville. Our predicted final score has Tennessee winning 79-76.
According to our model, the bookmakers have got it right, and Louisville and Tennessee each have a 50% chance of covering the spread, while the 156.5-point over/under also has an equal 50-50 chance of hitting.
Louisville vs. Tennessee odds
We have sourced the best men's college basketball odds in America for this game, which are listed here:
| Bet Type | Louisville | Tennessee |
|---|---|---|
| Spread | +4.5 (-110) | -4.5 (-110) |
| Moneyline | +168 | -192 |
| Total | o156.5 (-110) | u156.5 (-110) |
All odds are correct at the time of publication and are subject to change.
Louisville vs. Tennessee picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Louisville +4.5 | -110 |
| Moneyline | Louisville | +168 |
| Total | Under 156.5 | -110 |
According to our men's college basketball best bets, the top play to make on this game is Louisville to win.
Louisville vs. Tennessee game-day updates and essential details
Tuesday's men's college basketball action between Tennessee and Louisville at Thompson-Boling Arena is scheduled to begin at 7:00 PM ET.
- Who: Louisville vs. Tennessee
- Date: Tuesday, December 16, 2025
- Time: 7:00 PM ET/4:00PM PT
- Venue: Thompson-Boling Arena
Conclusion
We predict Tennessee, with a 63% win probability, will likely beat Louisville on Tuesday.
AI and automation have enhanced this article to quickly deliver accurate Louisville vs. Tennessee insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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