Louisville vs. Tennessee prediction: Why Tennessee is favored to win men's college basketball matchup [12/16/2025]

Tennessee and Louisville will meet in men's college basketball action at Thompson-Boling Arena on Tuesday, starting at 7:00 PM ET.

Based on updated simulations, Dimers' advanced college basketball model predicts Tennessee as the most likely winner of the Louisville vs. Tennessee game.

This article offers an expanded analysis of Tuesday's matchup, including an expanded look at the predicted score, best bets and picks.

Louisville vs. Tennessee prediction: Who will win and cover?

Using innovative machine learning and statistical analysis, we have simulated the outcome of Tuesday's NCAA basketball game between Louisville and Tennessee 10,000 times as part of our men's college basketball predictions coverage.

Our independent predictive model gives Tennessee a 60% chance of defeating Louisville. Our predicted final score has Tennessee winning 79-76.

According to our model, Tennessee (-1.5) has a 51% chance of covering the spread, while the over/under total of 157.5 points has a 52% chance of staying under.

Louisville vs. Tennessee odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Louisville vs. Tennessee picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: