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Read Article Dodgers vs. Astros prediction: Dodgers favored to win Wednesday's MLB matchup [5/6/2026]
Updated: | First published:
Written by Jason Bevilacqua, Head of Content and Communities
Get Los Angeles Dodgers vs Houston Astros predictions for MLB Wednesday.
The Houston Astros and Los Angeles Dodgers will lock horns in MLB action at Daikin Park on Wednesday, starting at 2:10 PM ET.
Lance McCullers (2-2, 6.32 ERA) will get the ball for the Astros, while the Dodgers have opted for Tyler Glasnow (3-0, 2.56 ERA).
Based on the latest simulations, Dimers' advanced MLB model projects the Dodgers as the most likely winner of the Dodgers vs. Astros game.
This article offers a closer look at Wednesday's matchup, including best bets and picks.
Dodgers vs. Astros prediction: Who will win and cover?
Using powerful machine learning and data, we have simulated the outcome of Wednesday's MLB matchup between the Dodgers and Astros, forming part of our MLB predictions coverage.
Our leading predictive model currently gives the Dodgers a 63% chance of beating the Astros.
According to our model, the bookmakers have got it right, and the Dodgers and Astros each have a 50% chance of covering the run line, while the over/under total of 8.5 runs has a 56% chance of going over.
Dodgers vs. Astros odds [5/6/2026]
We have researched the best MLB odds in America for this game, which are listed here:
| Bet Type | Dodgers | Astros |
|---|---|---|
| Run Line | -1.5 (-128) | +1.5 (+113) |
| Moneyline | -215 | +180 |
| Total | o8.5 (-114) | u8.5 (+100) |
All odds are correct at the time of publication and are subject to change.
Dodgers vs. Astros picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Astros +1.5 | +113 |
| Moneyline | Astros | +180 |
| Total | Over 8.5 | -114 |
According to our MLB best bets, the top play to make on this game is Astros +1.5 at the spread.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Dodgers vs. Astros game-day updates and essential details
Wednesday's MLB matchup between the Astros and Dodgers at Daikin Park is scheduled to commence at 2:10 PM ET.
- Who: Los Angeles Dodgers vs. Houston Astros
- Date: Wednesday, May 6, 2026
- Time: 2:10 PM ET/11:10AM PT
- Venue: Daikin Park
Conclusion
We predict the Dodgers, with a 63% win probability, will likely beat the Astros in Wednesday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.
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