Jacksonville Jaguars vs. Arizona Cardinals updated prediction featuring Travis Etienne, Trey McBride [Week 12, 2025]

Dimers' latest NFL predictions are live for Arizona Cardinals vs. Jacksonville Jaguars in Week 12, with our model giving the Jaguars a 56% of winning.

As Sunday approaches, both teams have updated their injury reports. Some lineup calls are still undecided, and those could shape how each side approaches this cross-conference battle.

Since our early Cardinals-Jaguars predictions, we’ve updated the win probabilities, score projections, and TD odds for Travis Etienne, Trey McBride, and others.

For the full simulation breakdown—including spreads, totals, touchdown probabilities, and the full list of player props—head to our Jaguars vs. Cardinals page.

What's changed? Jacksonville vs. Arizona updated predictions

Our NFL predictions model has been re-run with the newest available data, creating a clearer picture of how this Jaguars vs. Cardinals matchup stacks up. Here are the updated forecasts:

• Straight Up Win Probabilities: Jaguars 56%, Cardinals 44%
• Predicted Final Score: Jaguars 24-22 Cardinals
• Spread: Jaguars (-2.5) 42%, Cardinals (+2.5) 58%
• Total Points (47.5): Over 50%, Under 50%

As of November 20, 2025, these Jaguars-Cardinals numbers reflect changes since our early-week simulation.

Anytime touchdown scorer predictions

New NFL player projections for Week 12 highlight the top candidates to find the end zone in Jaguars-Cardinals on Sunday:

Jacksonville Jaguars

• Travis Etienne: 51.6% probability
• Bhayshul Tuten: 47.4% probability
• Brian Thomas: 32.5% probability

Arizona Cardinals

• Trey McBride: 46.4% probability
• Bam Knight: 40.7% probability
• Michael Wilson: 27.2% probability

Jaguars vs. Cardinals latest odds

The best current odds from the top sportsbooks in the US:

• Spread: Jaguars -2.5 (-122), Cardinals +2.5 (+100)
• Moneyline: Jaguars -154, Cardinals +140
• Total: Over/Under 47.5 (-105/-110)

Odds are correct at time of publication and are subject to change—track live updates via our NFL odds page.

Jaguars vs. Cardinals Week 12 details

The NFL Week 12 action between the Cardinals and Jaguars at State Farm Stadium is scheduled for November 23, 2025.

• Who: Jacksonville Jaguars vs. Arizona Cardinals
• Date: Sunday, November 23, 2025
• Time: 4:05PM ET/1:05PM PT
• Venue: State Farm Stadium

NFL Week 12 betting promos and codes

Make the most of Dimers' Jaguars vs. Cardinals predictions by exploring the two exciting offers below.

DraftKings Sportsbook

Sign up for DraftKings Sportsbook! Bet $5, get $200 in bonus bets instantly plus over $200 off NFL Sunday Ticket.

Bet365 Sportsbook

Join Bet365 Sportsbook! Bet $5, get $200 in bonus bets win or lose.

Conclusion

We predict the Jaguars, with a 56% win probability, will likely beat the Cardinals in Week 12 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Jaguars vs. Cardinals game, with human oversight maintaining high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee.

More on NFL

Stay informed with the latest NFL betting news and data-driven parlay picks all season long. Plus, our Super Bowl odds for top predictions and the best available odds on the Super Bowl, AFC, NFC and each division.