Jacksonville Jaguars vs. Arizona Cardinals: Experts release early Week 12 predictions [2025]

The Jacksonville Jaguars and Arizona Cardinals will meet in Week 12 of the NFL season at State Farm Stadium on Sunday, November 23, 2025, starting at 4:05PM ET.

Early simulations from Dimers' trusted NFL model favor the Jaguars as the most likely winner of this cross-conference meeting.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Jaguars vs. Cardinals predictions page.

Jacksonville vs. Arizona early predictions

Leveraging trusted machine learning and analysis, we have simulated the Jaguars vs. Cardinals game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Jaguars 56%, Cardinals 44%
• Predicted final score: Jaguars 24-22 Cardinals
• Spread: Jaguars (-2.5) 42%, Cardinals (+2.5) 58%
• Total points (47.5): Over 50%, Under 50%

As of November 17, 2025, these Jaguars-Cardinals numbers and predictions reflect the latest data and insights available.

Jaguars vs. Cardinals Week 12 details

The NFL Week 12 matchup between the Cardinals and Jaguars at State Farm Stadium is scheduled for November 23, 2025.

• Who: Jacksonville Jaguars vs. Arizona Cardinals
• Date: Sunday, November 23, 2025
• Time: 4:05PM ET/1:05PM PT
• Venue: State Farm Stadium

Jaguars vs. Cardinals opening odds

We've researched the best betting odds across America for this Week 12 game, which are listed here:

• Spread: Jaguars -2.5 (-112), Cardinals +2.5 (-105)
• Moneyline: Jaguars -146, Cardinals +125
• Total: Over/Under 47.5 (-105/-110)

Odds may continue to move—track live changes via our NFL odds page.

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Conclusion

We predict the Jaguars, with a 56% win probability, will likely beat the Cardinals in Week 12 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Jaguars vs. Cardinals matchup, with human oversight maintaining high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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