Jaguars vs. Cardinals prediction: Why Jacksonville is favored to win in NFL Week 12, 2025

The Arizona Cardinals and Jacksonville Jaguars are scheduled to meet in Week 12 of the NFL season at State Farm Stadium on Sunday, starting at 4:05PM ET.

Based on the latest simulations, Dimers' proven NFL model projects the Jaguars as the most likely winner of the Jaguars vs. Cardinals game.

This article offers an expanded analysis of this week's matchup, including projected touchdown scorers, best bets and player prop picks.

Jaguars vs. Cardinals prediction: Who will win and cover?

Since our Jaguars-Cardinals predictions earlier in the week, we have simulated the result of Sunday's NFL game between the Jaguars and Cardinals 10,000 times as part of our NFL predictions coverage.

Our independent predictive model currently gives the Jaguars a 56% chance of beating the Cardinals in Week 12 of the NFL season. Our predicted final score has the Jaguars winning 23-22.

According to our model, the Cardinals (+2.5) have a 58% chance of covering the spread, while the 47.5-point over/under has a 52% chance of staying under.

To see win probabilities for every matchup this week, check out our expert NFL Week 12 straight up picks.

Jaguars vs. Cardinals odds

We have sourced the best NFL odds in America for this game, which are listed here:

Bet Type	Jaguars	Cardinals
Spread	-2.5 (+100)	+2.5 (-114)
Moneyline	-134	+115
Total	o47.5 (-105)	u47.5 (-110)

All odds are correct at the time of publication and are subject to change.

Jaguars vs. Cardinals picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

Bet Type	Pick	Bet Now
Spread	Cardinals +2.5	-114
Moneyline	Jaguars	-134
Total	Under 47.5	-110

According to our NFL best bets, the top play to make on this game is Cardinals +2.5 at the spread.

Jaguars vs. Cardinals TD scorers

Who will score a touchdown in Jaguars vs. Cardinals?

According to our list of touchdown scorer predictions for today, Travis Etienne is most likely to score an anytime touchdown in Jaguars vs. Cardinals.

Our projections give Etienne a 45.6% chance of getting in for six at State Farm Stadium, while the running back is an 11.0% chance of scoring the first touchdown the game.

Anytime touchdown scorer predictions

Jacksonville Jaguars

Player	Anytime TD Probability
Travis Etienne (RB)	45.6%
Bhayshul Tuten (RB)	37.7%
Jakobi Meyers (WR)	28.4%
Trevor Lawrence (QB)	26.4%
Parker Washington (WR)	26.3%

Arizona Cardinals

Player	Anytime TD Probability
Trey McBride (TE)	45.4%
Bam Knight (RB)	43.3%
Michael Wilson (WR)	27.7%
Michael Carter (RB)	24.0%
Greg Dortch (WR)	21.6%

First touchdown scorer predictions

Jacksonville Jaguars

Player	First TD Probability
Travis Etienne (RB)	11.0%
Bhayshul Tuten (RB)	8.5%
Jakobi Meyers (WR)	6.0%
Trevor Lawrence (QB)	5.5%
Parker Washington (WR)	5.5%

Arizona Cardinals

Player	First TD Probability
Trey McBride (TE)	10.5%
Bam Knight (RB)	9.8%
Michael Wilson (WR)	5.6%
Michael Carter (RB)	4.7%
Greg Dortch (WR)	4.2%

Jaguars vs Cardinals player props

Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the Jaguars and Cardinals. Head to our NFL player projections page now to access a full list of player prop projections for every offensive player in this matchup and all other Week 12 games.

Quarterbacks

Of the starting quarterbacks, the Jaguars' Trevor Lawrence is projected for 226 passing yards. The Cardinals' Jacoby Brissett is expected to throw for 251 yards.

Player	Proj. Pass Yards
Trevor Lawrence (JAX)	226
Jacoby Brissett (ARI)	251

Jaguars rushing

Player	Proj. Rush Yards
Travis Etienne	53
Bhayshul Tuten	47
Trevor Lawrence	19

Cardinals rushing

Player	Proj. Rush Yards
Bam Knight	45
Michael Carter	23
Jacoby Brissett	15

Jaguars receiving

Player	Proj. Rec. Yards
Jakobi Meyers	59
Parker Washington	49
Brenton Strange	31
Tim Patrick	27
Travis Etienne	17

Cardinals receiving

Player	Proj. Rec. Yards
Trey McBride	75
Michael Wilson	64
Greg Dortch	34
Xavier Weaver	20
Elijah Higgins	18

Jaguars vs. Cardinals game-day updates and essential details

The NFL Week 12 game between the Cardinals and Jaguars at State Farm Stadium is scheduled to begin at 4:05PM ET.

• Who: Jacksonville Jaguars vs. Arizona Cardinals
• Date: Sunday, November 23, 2025
• Time: 4:05PM ET/1:05PM PT
• Venue: State Farm Stadium

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Conclusion

We predict the Jaguars, with a 56% win probability, will likely beat the Cardinals in Week 12 of the NFL season.

AI and automation have enhanced this article to quickly deliver accurate Jaguars vs. Cardinals insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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