NFL picks straight up: Week 12, 2025

At Dimers.com, we provide NFL picks straight up for Week 12 and every week, as part of our extensive NFL picks and NFL predictions coverage.

With Week 12 of the NFL season upon us, we've harnessed our powerful predictive analytics model to deliver a list of NFL straight up picks for all 14 games this week.

Gain the edge in your NFL pick 'em competitions via our data-driven NFL Week 12 picks straight up, powered by thousands of game simulations.

Week 12 of the NFL season features 14 games, beginning with the Buffalo Bills facing the Houston Texans on Thursday night and wrapping up with the Carolina Panthers taking on the San Francisco 49ers on Monday.

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Full list of NFL Week 12 picks straight up

• Bills (69% win probability)
• Packers (73%)
• Chiefs (62%)
• Patriots (70%)
• Bears (60%)
• Ravens (88%)
• Lions (80%)
• Seahawks (91%)
• Jaguars (56%)
• Raiders (62%)
• Eagles (59%)
• Saints (54%)
• Rams (71%)
• 49ers (72%)

NFL picks this week straight up: Week 12, 2025

Here are our Week 12 NFL picks, highlighting each team's chances of winning their game this week.

Buffalo Bills vs. Houston Texans

The Bills kick off Week 12 against the Texans at NRG Stadium on Thursday night. According to our model, the Bills have a 69% chance of winning, while the Texans have a 31% chance.

For Week 12's opening game, our model highlights NFL player props with James Cook (RB) as the most likely player from the Bills to score the first TD at 11.8%, while Woody Marks (RB) is the top candidate from the Texans at 10.7%.

The Buffalo Bills vs. Houston Texans game at NRG Stadium is scheduled for Thursday, November 20 at 8:15pm. All times stated in this article are in Eastern Standard Time (EST).

Minnesota Vikings vs. Green Bay Packers

For this week's game between the Vikings and the Packers, Green Bay is more likely to win. Our prediction model gives the Packers a 73% chance of winning. On the other hand, there is a 27% chance that the Vikings will pull off an upset win.

The Minnesota Vikings vs. Green Bay Packers matchup at Lambeau Field will take place on Sunday, November 23 at 1:00pm.

As the regular season approaches its conclusion, track the top teams with our updated NFL futures, highlighting top Super Bowl contenders.

Indianapolis Colts vs. Kansas City Chiefs

We are picking the Chiefs to win their game against the Colts this week, with our powerful NFL model projecting a 62% win probability for the home team. The Colts have a 38% chance of winning at GEHA Field at Arrowhead Stadium.

For betting purposes, the Chiefs are listed as -3.5 favorites, with the Colts' moneyline at +154.

The Indianapolis Colts vs. Kansas City Chiefs game at GEHA Field at Arrowhead Stadium is slated for Sunday, November 23 at 1:00pm.

New England Patriots vs. Cincinnati Bengals

According to our predictive analytics model, the Patriots are the team to beat in this game, with their win probability at 70%. The Bengals, on the other hand, have a 30% chance of winning.

The New England Patriots vs. Cincinnati Bengals game at Paycor Stadium is set for Sunday, November 23 at 1:00pm.

Pittsburgh Steelers vs. Chicago Bears

The Bears have a 60% chance of winning on Sunday afternoon, compared to the Steelers' 40% chance of victory. This makes the Chicago Bears our pick to win at Soldier Field.

The Pittsburgh Steelers vs. Chicago Bears matchup at Soldier Field is scheduled for Sunday, November 23 at 1:00pm.

New York Jets vs. Baltimore Ravens

The Ravens are favorites to win this one, with our predictive analytics model giving them an 88% chance, while the Jets enter the weekend with a 12% chance of causing an upset at M&T Bank Stadium.

When it comes to betting on this game, the Jets' moneyline odds are set at +700, with the home team Ravens listed as -13.5 favorites.

The New York Jets vs. Baltimore Ravens game at M&T Bank Stadium will take place on Sunday, November 23 at 1:00pm.

New York Giants vs. Detroit Lions

After 10,000 simulations of Giants vs. Lions this Sunday, our model projects the Lions as the more likely winners with a probability of 80%. Their opponents, the Giants, have a 20% chance of getting the win on the road.

The New York Giants vs. Detroit Lions matchup at Ford Field is slated for Sunday, November 23 at 1:00pm.

Seattle Seahawks vs. Tennessee Titans

DimersBOT is picking the Seahawks, who have a 91% chance of winning the matchup, while the Titans have a 9% win probability.

The Seattle Seahawks vs. Tennessee Titans game at Nissan Stadium will take place on Sunday, November 23 at 1:00pm.

Jacksonville Jaguars vs. Arizona Cardinals

The next game of Week 12 sees the Jaguars take on the Cardinals at State Farm Stadium.

We predict the Jaguars to win with a probability of 56%, while the Cardinals are projected to have a win chance of 44%.

As for the Vegas betting odds here, the Cardinals are listed as +2.5 underdogs, with the Jaguars' moneyline odds posted at -145.

The Jacksonville Jaguars vs. Arizona Cardinals game at State Farm Stadium is scheduled for Sunday, November 23 at 4:05pm.

Cleveland Browns vs. Las Vegas Raiders

The likely winner of this matchup is the Raiders, who have a projected win chance of 62%, according to DimersBOT. On the other side of this matchup, the Browns have a projected win probability of 38%.

The Cleveland Browns vs. Las Vegas Raiders matchup at Allegiant Stadium is set for Sunday, November 23 at 4:05pm.

Philadelphia Eagles vs. Dallas Cowboys

We have run our powerful NFL model over this week’s Eagles-Cowboys clash 10,000 times, with the Eagles coming out as the team to pick. Of those 10,000 simulations, the Eagles won 5,908 times, with the Cowboys winning on 4,092 occasions.

The Philadelphia Eagles vs. Dallas Cowboys game at AT&T Stadium is scheduled for Sunday, November 23 at 4:25pm.

Atlanta Falcons vs. New Orleans Saints

Next up is the game between the Falcons and Saints, with our model projecting the home team as the more likely victor, with the Saints rated as having a 54% chance of getting the W. The Falcons, on the other hand, are projected to have a 46% chance of winning.

For those interested in betting on this matchup, the oddsmakers have the Falcons' moneyline odds set at +110 for this road game, while the hosting Saints are listed as -1.5 favorites.

The Atlanta Falcons vs. New Orleans Saints game at Caesars Superdome will take place on Sunday, November 23 at 4:25pm.

Tampa Bay Buccaneers vs. Los Angeles Rams

Our next straight up pick this week is for the Rams to get the win against the Buccaneers. After running 10,000 simulations of this matchup, the LA Rams have a win probability of 71%, with the Buccaneers at 29%.

The Tampa Bay Buccaneers vs. Los Angeles Rams game at SoFi Stadium is slated for Sunday, November 23 at 8:20pm.

Carolina Panthers vs. San Francisco 49ers

With a win probability of 72% on Monday night, our straight up pick for this game is the 49ers, while their opponent, the Panthers, have a projected win chance of 28%.

The Carolina Panthers vs. San Francisco 49ers game at Levi's Stadium will take place on Monday, November 24 at 8:15pm.

For a different angle on this week's NFL action, explore our NFL trends to spot the latest player prop trends.

For more insights into this week's NFL predictions, check out the latest from the Dimers Sports Betting Podcast:

NFL straight up picks and predictions for Week 12

The NFL Week 12 predictions straight up in this article are accurate at the time of publication but may change.

Dimers.com is the best site for NFL predictions, with our straight up picks trusted by football fans across the country.

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Please note that all NFL odds and probabilities mentioned on this page are subject to change.