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Colts vs. Texans prediction: Houston favored to win in NFL Week 18 [2026]

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Written by Dave Garofolo

Get Indianapolis Colts vs Houston Texans predictions for NFL Sunday.

Indianapolis Colts-Houston Texans Predictions and Game Preview.
Indianapolis Colts vs. Houston Texans NFL prediction for Sunday, January 4, 2026.

The Houston Texans will take on the Indianapolis Colts in NFL Week 18 action at NRG Stadium on Sunday, beginning at 1:00 PM ET.

Based on the latest simulation results, Dimers' proven NFL model predicts the Texans as the most likely winner of the Colts vs. Texans game.

This article offers further insights into this week's matchup, including projected touchdown scorers, best bets and player prop picks.

Colts vs. Texans prediction: Who will win and cover?

Since our Colts-Texans predictions earlier in the week, we have simulated the result of Sunday's NFL game between the Colts and Texans 10,000 times as part of our NFL predictions coverage.

Our independent predictive model currently gives the Texans an 82% chance of beating the Colts in Week 18 of the NFL season. Our predicted final score has the Texans winning 22-14.

According to our model, the Colts (+9.5) have a 55% chance of covering the spread, while the over/under total of 37.5 points has an equal 50-50 chance of hitting.

 

To see win probabilities for every matchup this week, check out our expert NFL Week 18 straight up picks.

Colts vs. Texans odds

We have researched the best NFL odds in America for this game, which are listed here:

Bet Type Colts Texans
Spread +9.5 (-104) -9.5 (-110)
Moneyline +410 -535
Total o37.5 (-110) u37.5 (-108)

All odds are correct at the time of publication and are subject to change.

Colts vs. Texans picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

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Written by
Dave Garofolo
Content Producer

Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.

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