NFL picks straight up: Week 18, 2026

At Dimers, our Week 18 NFL picks are grounded in data-driven insight, with straight-up picks for all 16 games informed by our latest NFL predictions.

Get an edge in your NFL pick 'em competitions by following our data-driven NFL Week 18 picks straight up, powered by thousands of game simulations.

Week 18 of the NFL season starts with the Carolina Panthers facing the Tampa Bay Buccaneers on Saturday and concludied with the Baltimore Ravens taking on the Pittsburgh Steelers on Sunday night.

Full list of NFL Week 18 picks straight up

• Buccaneers (59% win probability)
• Seahawks (54%)
• Vikings (71%)
• Jaguars (84%)
• Texans (85%)
• Cowboys (64%)
• Bengals (76%)
• Falcons (61%)
• Patriots (82%)
• Rams (75%)
• Bears (58%)
• Eagles (74%)
• Bills (79%)
• Chiefs (72%)
• Broncos (90%)
• Ravens (62%)

NFL picks this week straight up: Week 18, 2026

Here are our Week 18 NFL picks, highlighting how likely each team is to win their game this week.

Carolina Panthers vs. Tampa Bay Buccaneers

The Panthers kick off Week 18 against the Buccaneers at Raymond James Stadium on Saturday. According to our predictive analytics model, the Buccaneers have a 59% chance of winning, while the Panthers have a 41% chance.

For Week 18's opening game, our model highlights NFL player props with Tetairoa McMillan (WR) as the most likely player from the Panthers to score the first TD at 9.5%, while Mike Evans (WR) is the top candidate from the Buccaneers at 10.3%.

The Carolina Panthers vs. Tampa Bay Buccaneers game at Raymond James Stadium is scheduled for Saturday, January 3 at 4:30pm. All times mentioned in this article are in Eastern Standard Time (EST).

Seattle Seahawks vs. San Francisco 49ers

For this week's game between the Seahawks and the 49ers, Seattle is more likely to win. Our prediction model gives the Seahawks a 54% chance of winning. On the other hand, there is a 46% chance that the 49ers will win.

The Seattle Seahawks vs. San Francisco 49ers matchup at Levi's Stadium will take place on Saturday, January 3 at 8:00pm.

As the playoffs apporoach, track the top teams with our updated NFL futures, highlighting top Super Bowl contenders.

Green Bay Packers vs. Minnesota Vikings

We are picking the Vikings to win their game against the Packers this week, with our famous NFL model projecting a 71% win probability for the home team. The Packers have a 29% chance of winning.

For betting purposes, the Vikings are listed as -6.5 favorites, with the Packers' moneyline at +230.

The Green Bay Packers vs. Minnesota Vikings game at U.S. Bank Stadium is slated for Sunday, January 4 at 1:00pm.

Tennessee Titans vs. Jacksonville Jaguars

According to our predictive analytics model, the Jaguars are the team to beat in this game, with their win probability at 84%. The Titans, on the other hand, have a 16% chance of winning.

The Tennessee Titans vs. Jacksonville Jaguars game at EverBank Stadium is set for Sunday, January 4 at 1:00pm.

Indianapolis Colts vs. Houston Texans

The Texans have an 85% chance of winning on Sunday afternoon, compared to the Colts' 15% chance of victory. This makes the Houston Texans our pick to win at NRG Stadium.

The Indianapolis Colts vs. Houston Texans matchup at NRG Stadium is scheduled for Sunday, January 4 at 1:00pm.

Dallas Cowboys vs. New York Giants

The Cowboys are favorites to win their game this week, with our model giving them a 64% chance, while the Giants enter the weekend with a 36% chance of causing an upset at MetLife Stadium.

When it comes to betting on this game, the Cowboys' moneyline odds are set at -225, with the home team Giants listed as +4.5 underdogs.

The Dallas Cowboys vs. New York Giants game at MetLife Stadium will take place on Sunday, January 4 at 1:00pm.

Cleveland Browns vs. Cincinnati Bengals

After 10,000 simulations of Browns vs. Bengals this Sunday, our model projects the Bengals as the more likely winners with a probability of 76%. Their opponents, the Browns, have a 24% chance of getting the win on the road.

The Cleveland Browns vs. Cincinnati Bengals matchup at Paycor Stadium is slated for Sunday, January 4 at 1:00pm.

New Orleans Saints vs. Atlanta Falcons

DimersBOT is picking the Falcons, who have a 61% chance of winning the matchup, while the Saints have a 39% chance of an upset win.

The New Orleans Saints vs. Atlanta Falcons game at Mercedes-Benz Stadium will take place on Sunday, January 4 at 1:00pm.

Miami Dolphins vs. New England Patriots

The next game of Week 18 sees the Dolphins take on the Patriots at Gillette Stadium.

We predict the Patriots to win with a probability of 82%, while the Dolphins are projected to have a win chance of 18%.

As for the Vegas betting odds here, the Patriots are listed as -11.5 favorites, with the Dolphins' moneyline odds posted at +530.

The Miami Dolphins vs. New England Patriots game at Gillette Stadium is scheduled for Sunday, January 4 at 4:25pm.

Arizona Cardinals vs. Los Angeles Rams

The likely winner of this matchup is the Rams, who have a projected win chance of 75%, according to DimersBOT. On the other side of this matchup, the Cardinals have a projected win probability of 25%.

The Arizona Cardinals vs. Los Angeles Rams matchup at SoFi Stadium is set for Sunday, January 4 at 4:25pm.

Detroit Lions vs. Chicago Bears

We have run our powerful NFL model over this week’s Lions-Bears clash 10,000 times, with the Bears coming out as the team to pick. Of those 10,000 simulations, the Bears won 5,759 times, with the Lions winning on 4,241 occasions.

The Detroit Lions vs. Chicago Bears game at Soldier Field is scheduled for Sunday, January 4 at 4:25pm.

Washington Commanders vs. Philadelphia Eagles

Next up is the game between the Commanders and Eagles, with our model projecting the home team as the more likely victor, with the Eagles rated as having a 74% chance of getting the W. The Commanders, on the other hand, are projected to have a 26% chance of winning.

For those interested in betting on this matchup, the oddsmakers have the Commanders' moneyline odds set at +280 for this road game, while the hosting Eagles are listed as -7 favorites.

The Washington Commanders vs. Philadelphia Eagles game at Lincoln Financial Field will take place on Sunday, January 4 at 4:25pm.

New York Jets vs. Buffalo Bills

Our next straight up pick this week is for the Bills to get the win against the Jets. After running 10,000 simulations of this matchup, the Buffalo have a win probability of 79%, with the Jets at 21%.

The New York Jets vs. Buffalo Bills game at Highmark Stadium is slated for Sunday, January 4 at 4:25pm.

Kansas City Chiefs vs. Las Vegas Raiders

With a win probability of 72% on Sunday afternoon, our straight up pick for this matchup is the Chiefs, while their opponent, the Raiders, have a projected win chance of 28%.

The Kansas City Chiefs vs. Las Vegas Raiders game at Allegiant Stadium will take place on Sunday, January 4 at 4:25pm.

For a different angle on this week's NFL action, explore our NFL trends to find the latest player prop trends.

Los Angeles Chargers vs. Denver Broncos

The team to pick here is the Broncos, who have a 90% chance of winning their matchup against the Chargers this Sunday afternoon.

Looking at the betting odds for this Sunday afternoon clash, the Broncos are listed as -12.5 favorites at home, with the Chargers' moneyline odds available at +575.

The Los Angeles Chargers vs. Denver Broncos game at Empower Field at Mile High is scheduled for Sunday, January 4 at 4:25pm.

Baltimore Ravens vs. Pittsburgh Steelers

Our pick to win the final game of Week 18 is the Ravens, who have a win probability of 62%. Their opponents are projected to have a 38% chance of getting the W.

The Baltimore Ravens vs. Pittsburgh Steelers game at Acrisure Stadium is set for Sunday, January 4 at 8:20pm.

For more insights into this week's NFL predictions, check out the latest from the Dimers Sports Betting Podcast:

NFL straight up picks and predictions for Week 18

The NFL Week 18 predictions straight up in this article are accurate at the time of publication but may change.

Dimers.com is the best site for NFL predictions, with our straight up picks trusted by football fans across the country.

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Please note that all NFL odds and probabilities mentioned on this page are subject to change.