Pacers vs. Cavaliers prediction: Cleveland to win, Donovan Mitchell projected for big game in Friday's NBA Cup matchup [11/21/2025]

NBA Cup action continues on Friday at 7:00PM ET as the Indiana Pacers take on the Cleveland Cavaliers at Rocket Arena.

Based on the latest simulations and today’s injury updates, Dimers' proven NBA model predicts the Cavaliers as the most likely winner of the Pacers vs. Cavaliers game.

This prediction follows the latest NBA Injury Report, which suggests the Cavaliers lineup will feature players like Donovan Mitchell, Darius Garland and Evan Mobley, while the Pacers will look to Pascal Siakam, Bennedict Mathurin and Andrew Nembhard.

This article offers an expanded analysis of Friday's matchup, including an expanded look at the predicted score, best bets and player prop picks.

Pacers vs. Cavs prediction: Who will win NBA Cup game?

As part of Dimers' NBA predictions coverage—and following a review of recent results—our pregame model has generated moneyline, spread, and over/under probabilities for Friday's clash between the Pacers and Cavaliers.

Our leading predictive model currently gives the Cavaliers an 84% chance of defeating the Pacers. Our predicted final score has the Cavaliers winning 125-114.

According to our model, the Pacers (+13.5) have a 57% chance of covering the spread, while the over/under total of 241.5 points has a 54% chance of staying under.

Pacers vs. Cavaliers odds

We have researched the best NBA odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Pacers vs. Cavaliers picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our best NBA bets for Friday, the top play to make on this game is Pacers +13.5 at the spread.

Pacers vs. Cavaliers player props

NBA player props are an exciting way to wager on the Pacers vs. Cavaliers matchup without necessarily betting on the outcome. We use the best information available to project how each team's leading players will perform at Rocket Arena.

Pascal Siakam is expected to lead the Pacers with 25 points, 7 rebounds and 5 assists, while Donovan Mitchell is projected to have 27 points, 5 rebounds and 5 assists for the Cavaliers.

Check out our NBA player projections for a full range of projected box scores, including points, assists, rebounds and more, for every game this season.

Pacers prediction

Our model's projected player stats for the Pacers are:

Cavaliers prediction

Projected points, rebounds, assists and three-pointers made for the Cavaliers:

Pacers vs. Cavs game-day updates and essential details

Friday's game between the Cavaliers and Pacers at Rocket Arena is scheduled to start at 7:00PM ET.

• Who: Indiana Pacers vs. Cleveland Cavaliers
• Date: Friday, November 21, 2025
• Time: 7:00PM ET/4:00PM PT
• Venue: Rocket Arena
• Tournament details: 2025 Emirates NBA Cup

Conclusion

We predict the Cavaliers, with an 84% win probability, will likely beat the Pacers on Friday, with Donovan Mitchell projected for a game-high 48 fantasy points.

AI and automation have enhanced this article to quickly deliver accurate Pacers vs. Cavaliers insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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