Rockets vs. Thunder prediction: Oklahoma City favored to win on NBA Opening Night [10/21/2025]

The Oklahoma City Thunder will square off with the Houston Rockets in NBA Opening Night action at Paycom Center on Tuesday, starting at 7:30PM ET.

Based on updated simulation results and today’s injury reports, Dimers' advanced NBA model predicts the Thunder as the most likely winner of today's game.

This prediction follows the latest NBA Injury Report, which suggests the Thunder lineup will feature stars like Shai Gilgeous-Alexander, Chet Holmgren and Aaron Wiggins, while the Rockets will rely on Kevin Durant, Alperen Sengun and Amen Thompson.

For expanded analysis of Tuesday's matchup, including an expanded look at the predicted score, best bets and player prop picks, visit our interactive Rockets vs. Thunder predictions page.

Rockets vs. Thunder prediction: Who will win, cover the spread?

Using powerful machine learning and data analysis, we have simulated the result of Tuesday's NBA game between the Rockets and Thunder 10,000 times as part of our NBA predictions coverage.

Our leading predictive model gives the Thunder a 72% chance of beating the Rockets. Our predicted final score has the Thunder winning 115-109.

According to our model, the bookmakers have got it right, and the Rockets and Thunder each have a 50% chance of covering the spread, while the over/under total of 225.5 points has a 51% chance of staying under.

Rockets vs. Thunder odds

We have researched the best NBA odds in America for this game, which are listed here:

Bet Type	Rockets	Thunder
Spread	+6.5 (-110)	-6.5 (-108)
Moneyline	+205	-245
Total	o225.5 (-108)	u225.5 (-105)

All odds are correct at the time of publication and are subject to change.

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Rockets vs. Thunder picks and best bets

Our model's biggest edge in today's Rockets vs. Thunder matchup is on the moneyline.

Our expert predictions, aligned with the latest odds, reveal the best NBA picks and NBA best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Rockets vs. Thunder player props

Looking for Rockets vs. Thunder NBA player props? We use the best information available to project how each team's leading players will perform at Paycom Center.

Kevin Durant is expected to lead the Rockets in scoring, while Shai Gilgeous-Alexander is projected to be the top scorer for the Thunder.

Dimers Pro users can access a full range of player props and projected box scores, including points, assists, rebounds and more, for every NBA game this season.

Rockets vs. Thunder game-day updates and essential details

Tuesday's matchup between the Thunder and Rockets at Paycom Center is scheduled to start at 7:30PM ET.

• Who: Houston Rockets vs. Oklahoma City Thunder
• Date: Tuesday, October 21, 2025
• Time: 7:30PM ET/4:30PM PT
• Venue: Paycom Center

Dimers' comprehensive preview of Tuesday's Rockets vs. Thunder matchup includes our prediction, picks and the latest betting odds.

Before making any Rockets vs. Thunder picks, be sure to check out the latest NBA predictions and betting advice from Dimers Pro.

Conclusion

We predict the Thunder, with a 72% win probability, will likely beat the Rockets on Tuesday.

AI and automation have enhanced this article to quickly deliver accurate Rockets vs. Thunder insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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