Tigers vs. Mariners prediction: Detroit favored to win Game 5 of ALDS [10/10/2025]

MLB action continues on Friday at 8:08PM ET as the Detroit Tigers lock horns with the Seattle Mariners in Game 5 of the American League Division Series at T-Mobile Park.

The Mariners will have George Kirby (0-0, 3.60 ERA in 2025 postseason) as their starting pitcher, pitting him against Cy Young hopeful Tarik Skubal (1-0, 1.84 ERA) for the Tigers.

Based on the latest simulations, Dimers' advanced MLB model predicts the Tigers as the most likely winner of today's game.

For a closer look at Friday's matchup, including best bets and picks, visit our interactive Tigers vs. Mariners predictions page.

Tigers vs. Mariners prediction: Who will win Game 5?

Using powerful machine learning and data, we have simulated the result of Friday's MLB game between the Tigers and Mariners 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Tigers a 51% chance of beating the Mariners.

According to our model, the Mariners (+1.5) have a 63% chance of covering the run line, while the 5.5-run over/under has a 68% chance of going over.

Tigers vs. Mariners Game 5 odds [10/10/2025]

We have researched the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

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Tigers vs. Mariners picks and best bets for Game 5

Our model's biggest edge in today's Tigers vs. Mariners matchup is on the run line.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Tigers vs. Mariners game-day updates and essential details

Friday's MLB game between the Mariners and Tigers at T-Mobile Park is scheduled to start at 8:08PM ET.

• Who: Detroit Tigers vs. Seattle Mariners
• Date: Friday, October 10, 2025
• Time: 8:08PM ET/5:08PM PT
• Venue: T-Mobile Park

Dimers' full preview of Friday's Tigers vs. Mariners matchup includes our prediction, picks and the latest betting odds.

Before making any Tigers vs. Mariners picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Tigers, with a 51% win probability, will likely beat the Mariners on Friday.

AI and automation have enhanced this article to quickly deliver accurate Tigers vs. Mariners insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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