Jun 21, 2026
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Read Article Guardians vs. Astros prediction: Houston favored to win Sunday's MLB matchup [6/21/2026]
Updated: | First published:
Written by Jason Bevilacqua, Head of Content and Communities
Get Cleveland Guardians vs Houston Astros predictions for MLB Sunday.
The Houston Astros and Cleveland Guardians will lock horns in MLB action at Daikin Park on Sunday, starting at 2:10 PM ET.
The Astros will send Kai-Wei Teng (3-6, 4.31 ERA) to the mound, up against Slade Cecconi (3-5, 4.60 ERA) for the Guardians.
Based on the latest simulation results, Dimers' proven MLB model projects the Astros as the most likely winner of the Guardians vs. Astros game.
This article offers an expanded analysis of Sunday's matchup, including best bets and picks.
Guardians vs. Astros prediction: Who will win and cover?
Using trusted machine learning and data, we have simulated the result of Sunday's MLB matchup between the Guardians and Astros, forming part of our MLB predictions coverage.
Our famous predictive model currently gives the Astros a 59.6% chance of defeating the Guardians.
According to our model, the Guardians (+1.5) have a 57.5% chance of covering the run line, while the 8.5-run over/under has a 51.2% chance of going over,.
Guardians vs. Astros odds [6/21/2026]
We have sourced the best MLB odds in America for this game, which are listed here:
| Bet Type | Guardians | Astros |
|---|---|---|
| Run Line | +1.5 (-181) | -1.5 (+155) |
| Moneyline | +116 | -136 |
| Total | o8.5 (-112) | u8.5 (+100) |
All odds are correct at the time of publication and are subject to change.
Guardians vs. Astros picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Astros -1.5 | +155 |
| Moneyline | Astros | -136 |
| Total | Over 8.5 | -112 |
According to our best MLB bets, the top play to make on this game is Astros -1.5 at the spread.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Guardians vs. Astros game-day updates and essential details
Sunday's MLB matchup between the Astros and Guardians at Daikin Park is scheduled to commence at 2:10 PM ET.
- Who: Cleveland Guardians vs. Houston Astros
- Date: Sunday, June 21, 2026
- Time: 2:10 PM ET/11:10AM PT
- Venue: Daikin Park
Conclusion
We predict the Astros, with a 59.6% win probability, will likely beat the Guardians in Sunday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.
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