Guardians vs. Cubs Prediction: Cubs Predicted to Win Thursday's MLB Matchup [7/3/2025]

The Chicago Cubs and Cleveland Guardians are scheduled to meet in MLB action at Wrigley Field on Thursday, starting at 8:05PM ET.

The Cubs will start Cade Horton (3-2, 4.80 ERA), up against Joey Cantillo (1-0, 3.81 ERA) for the Guardians.

Based on the latest simulation results, Dimers' proven MLB model (see Dimers Pro for full access) projects the Cubs as the most likely winner of today's game.

"Using the latest data, our experts simulated Thursday's Guardians-Cubs game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"Taking into account recent updates and various additional inputs, we forecast the Cubs with a win probability of 55% and the Guardians with 45%."

For further insights into Thursday's matchup, including best bets and picks, visit our interactive Guardians vs. Cubs predictions page.

Cubs vs. Guardians Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and statistical analysis, we have simulated the outcome of Thursday's MLB matchup between the Guardians and Cubs 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently gives the Cubs a 55% chance of defeating the Guardians.

According to our model, the Guardians (+1.5) have a 63% chance of covering the run line, while the 8.5-run over/under has a 53% chance of staying under.

Guardians vs. Cubs Odds [7/3/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Guardians	Cubs
Run Line	+1.5 (-175)	-1.5 (+153)
Moneyline	+118	-134
Total	o8.5 (-102)	u8.5 (-115)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Guardians vs. Cubs Picks and Best Bets

Our model's biggest edge in today's Guardians vs. Cubs matchup is on the run line.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets Video

Calling Our Shot produces daily MLB betting content, including the latest free picks featured below.

Guardians vs. Cubs Game-Day Updates and Essential Details

Thursday's MLB game between the Cubs and Guardians at Wrigley Field is scheduled to start at 8:05PM ET.

• Who: Cleveland Guardians vs. Chicago Cubs
• Date: Thursday, July 3, 2025
• Time: 8:05PM ET/5:05PM PT
• Venue: Wrigley Field

Dimers.com's comprehensive preview of Thursday's Guardians vs. Cubs matchup includes our prediction, picks and the latest betting odds.

Before making any Guardians vs. Cubs picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Cubs, with a 55% win probability, will likely beat the Guardians on Thursday.

AI and automation have enhanced this article to quickly deliver accurate Guardians vs. Cubs insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Stay up-to-date with the latest MLB news and MLB parlay picks throughout the season. Plus, our World Series odds provide the latest projections for the World Series, American League, National League and each division.