Reds vs. Guardians Prediction: Cincinnati Predicted to Win Wednesday's MLB Matchup [6/11/2025]

The Cleveland Guardians will face the Cincinnati Reds in MLB action at Progressive Field on Wednesday, starting at 1:10PM ET.

The Guardians will send Logan Allen (3-4, 4.42 ERA) to the mound, while the Reds have opted for Nick Lodolo (4-4, 3.21 ERA).

Based on the latest simulations, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Reds as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Cincinnati-Cleveland game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Reds' chance of winning at 51%, with the Guardians at 49%."

For further insights into Wednesday's matchup, including best bets and picks, visit our interactive Reds vs. Guardians predictions page.

Guardians vs. Reds Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data, we have simulated the result of Wednesday's MLB matchup between the Reds and Guardians 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently gives the Reds a 51% chance of beating the Guardians.

According to our model, the Guardians (+1.5) have a 63% chance of covering the run line, while the over/under total of 8.5 runs has a 52% chance of staying under.

Reds vs. Guardians Odds [6/11/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Reds	Guardians
Run Line	-1.5 (+140)	+1.5 (-166)
Moneyline	-117	+108
Total	o8.5 (-120)	u8.5 (+100)

All odds are correct at the time of publication and are subject to change.

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Reds vs. Guardians Picks and Best Bets

Our model's biggest edge in today's Reds vs. Guardians matchup is on the run line.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets Video

Calling Our Shot produces daily MLB betting content, including the free picks featured below.

Reds vs. Guardians Game-Day Updates and Essential Details

Wednesday's MLB action between the Guardians and Reds at Progressive Field is scheduled to start at 1:10PM ET.

• Who: Cincinnati Reds vs. Cleveland Guardians
• Date: Wednesday, June 11, 2025
• Time: 1:10PM ET/10:10AM PT
• Venue: Progressive Field

Dimers.com's full preview of Wednesday's Reds vs. Guardians matchup includes our prediction, picks and the latest betting odds.

Before making any Cincinnati vs. Cleveland picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Reds, with a 51% win probability, will likely beat the Guardians on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Reds vs. Guardians insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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