May 16, 2026
Giants vs. Athletics prediction: Why Athletics is favored to win Saturday's MLB matchup [5/16/2026]
Read Article Cubs vs. White Sox prediction: Why Cubs are favored to win Saturday's MLB matchup [5/16/2026]
Updated: | First published:
Written by Jason Bevilacqua, Head of Content and Communities
Get Chicago Cubs vs Chicago White Sox predictions for MLB Saturday.
The Chicago White Sox and Chicago Cubs are scheduled to meet in MLB action at Rate Field on Saturday, starting at 7:10 PM ET.
Davis Martin (5-1, 1.62 ERA) will be the starting pitcher for the White Sox, up against Jameson Taillon (2-2, 3.94 ERA) for the Cubs.
Based on the latest simulation results, Dimers' advanced MLB model gives the Cubs a slight edge with a 51% win probability over the White Sox.
This article offers a closer look at Saturday's Cubs vs. White Sox matchup, including best bets and picks.
Cubs vs. White Sox prediction: Who will win and cover?
Using trusted machine learning and statistical analysis, we have simulated the outcome of Saturday's MLB matchup between the Cubs and White Sox, forming part of our MLB predictions coverage.
Our leading predictive model gives the Cubs a 51% chance of defeating the White Sox.
According to our model, the White Sox (+1.5) have a 61% chance of covering the run line, while the over/under total of 8.5 runs has a 54% chance of going over.
Cubs vs. White Sox odds [5/16/2026]
We have sourced the best MLB odds in America for this game, which are listed here:
| Bet Type | Cubs | White Sox |
|---|---|---|
| Run Line | -1.5 (+152) | +1.5 (-180) |
| Moneyline | -105 | -110 |
| Total | o8.5 (-110) | u8.5 (-104) |
All odds are correct at the time of publication and are subject to change.
Cubs vs. White Sox picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Cubs -1.5 | +152 |
| Moneyline | Cubs | -105 |
| Total | Over 8.5 | -110 |
According to our MLB best bets, the top play to make on this game is Over 8.5 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Cubs vs. White Sox game-day updates and essential details
Saturday's MLB matchup between the White Sox and Cubs at Rate Field is scheduled to commence at 7:10 PM ET.
- Who: Chicago Cubs vs. Chicago White Sox
- Date: Saturday, May 16, 2026
- Time: 7:10 PM ET/4:10PM PT
- Venue: Rate Field
Conclusion
We predict the Cubs, with a 51% win probability, will likely beat the White Sox in Saturday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
Continue reading with Dimers Pro
Join now to unlock this article and get full access to our predictions and betting tools. Cancel anytime.
$0 for 3 days
then $14.99/week
Already a Pro member? Log in
New here? See everything Pro includes
Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.
Advertiser disclosure
