Bulls vs. Trail Blazers prediction: Why Chicago is favored to win Wednesday's NBA game [11/19/2025]

The Portland Trail Blazers will take on the Chicago Bulls in NBA action at Moda Center on Wednesday, starting at 10:00PM ET.

Based on the latest simulation results and today’s injury updates, Dimers' proven NBA model predicts the Bulls as the most likely winner of the Bulls vs. Trail Blazers game.

This prediction follows the latest NBA Injury Report, which suggests the Trail Blazers lineup will feature stars like Deni Avdija, Jerami Grant and Toumani Camara, while the Bulls will look to Josh Giddey, Coby White and Nikola Vucevic.

This article offers further insights into Wednesday's matchup, including an expanded look at the predicted score, best bets and player prop picks.

Bulls vs. Blazers prediction: Who will win and cover?

As part of Dimers' NBA predictions coverage—and following a review of recent results—our pregame model has generated moneyline, spread, and over/under probabilities for Wednesday's clash between the Bulls and Trail Blazers.

According to our model, the Bulls (-3.5) have a 52% chance of covering the spread, while the 244.5-point over/under has a 54% chance of staying under.

Bulls vs. Trail Blazers odds

We have sourced the best NBA odds in America for this game, which are listed here:

Bet Type	Bulls	Trail Blazers
Spread	-3.5 (-105)	+3.5 (-110)
Moneyline	-158	+136
Total	o244.5 (-114)	u244.5 (-106)

All odds are correct at the time of publication and are subject to change.

Bulls vs. Trail Blazers picks and best bet

After matching our probabilities against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

Bet Type	Pick	Bet Now
Spread	Bulls -3.5	-105
Moneyline	Bulls	-158
Total	Under 244.5	-106

According to our best NBA bets for Wednesday, the top play to make on this game is Bulls to win.

Bulls vs. Trail Blazers player props

Betting on Chicago vs. Portland NBA player props? We have crunched the numbers to project how each team's leading players will perform at Moda Center.

Josh Giddey is expected to lead the Bulls with 19 points, 9 rebounds and 8 assists, while Deni Avdija is projected to have 25 points, 8 rebounds and 6 assists for the Trail Blazers.

Check out our NBA player projections for a full range of projected box scores, including points, assists, rebounds and more, for every game this season.

Bulls prediction

Our model's projected player stats for the Bulls are:

Player	PTS	REB	AST	3PM	DFS
Josh Giddey	19	9	8	1	50
Coby White	19	3	4	2	33
Nikola Vucevic	16	9	4	2	37
Matas Buzelis	15	5	2	2	30
Kevin Huerter	13	4	3	2	27

Trail Blazers prediction

Projected points, rebounds, assists and three-pointers made for the Trail Blazers:

Player	PTS	REB	AST	3PM	DFS
Deni Avdija	25	8	6	2	50
Jerami Grant	18	4	3	2	32
Toumani Camara	14	6	3	2	32
Caleb Love	13	6	5	3	32
Sidy Cissoko	12	3	3	2	25

Bulls vs. Blazers game-day updates and essential details

Wednesday's matchup between the Trail Blazers and Bulls at Moda Center is scheduled to start at 10:00PM ET.

• Who: Chicago Bulls vs. Portland Trail Blazers
• Date: Wednesday, November 19, 2025
• Time: 10:00PM ET/7:00PM PT
• Venue: Moda Center

Conclusion

We predict the Bulls, with a 64% win probability, will likely beat the Trail Blazers on Wednesday, with Deni Avdija projected for a game-high 50 fantasy points.

AI and automation have enhanced this article to quickly deliver accurate Bulls vs. Trail Blazers insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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