Carolina Panthers vs. San Francisco 49ers updated prediction featuring Rico Dowdle, Christian McCaffrey [Week 12, 2025]

Dimers' latest NFL predictions are live for San Francisco 49ers vs. Carolina Panthers in Week 12, with our model giving the 49ers a 74% of winning.

As Monday approaches, both teams have updated their injury reports. A few lineup decisions are still up in the air, and those could shape how each side approaches this NFC clash.

Since our early 49ers-Panthers predictions, we’ve updated the win probabilities, score projections, and TD odds for Rico Dowdle, Christian McCaffrey, and others.

For the full simulation breakdown—including spreads, totals, touchdown probabilities, and the full list of player props—head to our Panthers vs. 49ers page.

What's changed? Carolina vs. San Francisco updated predictions

Our NFL predictions model has been re-run with the newest available data, creating a clearer picture of how this Panthers vs. Niners matchup stacks up. Here are the updated forecasts:

• Straight Up Win Probabilities: Panthers 26%, 49ers 74%
• Predicted Final Score: Panthers 20-28 49ers
• Spread: Panthers (+7) 50%, 49ers (-7) 50%
• Total Points (48.5): Over 50%, Under 50%

As of November 20, 2025, these Panthers-49ers figures reflect changes since our early-week simulation.

Anytime touchdown scorer predictions

New NFL player projections for Week 12 highlight the top candidates to find the end zone in Panthers-Niners on Monday:

Carolina Panthers

• Rico Dowdle: 49.1% probability
• Tetairoa McMillan: 35.1% probability
• Xavier Legette: 20.9% probability

San Francisco 49ers

• Christian McCaffrey: 69.8% probability
• George Kittle: 41.2% probability
• Jauan Jennings: 31.3% probability

Panthers vs. Niners latest odds

The best current odds from the top sportsbooks in the US:

• Spread: Panthers +7 (-105), 49ers -7 (-110)
• Moneyline: Panthers +280, 49ers -345
• Total: Over/Under 48.5 (-105/-110)

Odds are correct at time of publication and are subject to change—track live updates via our NFL odds page.

Panthers vs. Niners Week 12 details

The NFL Week 12 matchup between the 49ers and Panthers at Levi's Stadium is scheduled for November 24, 2025.

• Who: Carolina Panthers vs. San Francisco 49ers
• Date: Monday, November 24, 2025
• Time: 8:15PM ET/5:15PM PT
• Venue: Levi's Stadium

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Conclusion

We predict the 49ers, with a 74% win probability, will likely beat the Panthers in Week 12 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Panthers vs. 49ers matchup, with human oversight maintaining high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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