Carolina Panthers vs. San Francisco 49ers: Experts release early Week 12 preview [2025]

The Carolina Panthers and San Francisco 49ers will meet in Week 12 of the NFL season at Levi's Stadium on Monday, November 24, 2025, starting at 8:15PM ET.

Early simulations from Dimers' trusted NFL model favor the 49ers as the most likely winner of this NFC clash.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Panthers vs. 49ers predictions page.

Carolina vs. San Francisco early predictions

Leveraging trusted machine learning and analysis, we have simulated the Panthers vs. Niners game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Panthers 28%, 49ers 72%
• Predicted final score: Panthers 20-26 49ers
• Spread: Panthers (+7) 54%, 49ers (-7) 46%
• Total points (46.5): Over 50%, Under 50%

As of November 17, 2025, these Panthers-49ers calculations and predictions reflect the latest data and insights available.

Panthers vs. Niners Week 12 details

The NFL Week 12 action between the 49ers and Panthers at Levi's Stadium is scheduled for November 24, 2025.

• Who: Carolina Panthers vs. San Francisco 49ers
• Date: Monday, November 24, 2025
• Time: 8:15PM ET/5:15PM PT
• Venue: Levi's Stadium

Panthers vs. Niners opening odds

We've researched the best betting odds across America for this Week 12 game, which are listed here:

• Spread: Panthers +7 (-115), 49ers -7 (-105)
• Moneyline: Panthers +250, 49ers -310
• Total: Over/Under 46.5 (-110/-110)

Odds may continue to move—track live changes via our NFL odds page.

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Conclusion

We predict the 49ers, with a 72% win probability, will likely beat the Panthers in Week 12 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Panthers vs. 49ers matchup, with human oversight maintaining high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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